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PPP 2 > Diuretics > Flashcards

Diuretics Flashcards

1
Q

Diuretic

A

= agent that increases rate of urine flow

Most via increased Na excretion

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2
Q

Acetazolamide

A

CAI

MOA: decrease H secretion = decrease Na reabsorption = increase Na excretion

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3
Q

Furosemide, Bumetanide

A

Loop Diuretics

MOA: inhibit NKCC2 in TAL = decrease Na reabsorption = increase Na excretion

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4
Q

Hydrochlorothiazide, Chlorothiazide

A

Thiazide Diuretics

MOA: inhibit NCC in DCT = decrease Na reabsorption = increase Na excretion

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5
Q

Amiloride, Triamterene, Spironolactone

A

K-sparing Diuretics

MOA: block ENaC

Spirono/Eplerenone: inhibit ald. binding to MR = decrease stimulation of ENaC

= all decrease Na reabsorption in CNT/CD

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6
Q

Increased Na reabsorption =

A

Increased K secretion

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7
Q

Effects of Diuretics on K

A

CAI/LD/TZ = Hypokalemia

K-sparing = Hyperkalemia

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8
Q

Effects of Diuretics on H/HCO3

A

LD/TZ = Metabolic Alkalosis

CAI/K-sparing = Metabolic Acidosis

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9
Q

Effects of Diuretics on Ca

A

TZ = Hypercalcemia

LD = Hypocalcemia

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10
Q

Effects of Diuretics on Mg

A

LD/TZ = Hypomagnesemia

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11
Q

Effects of Diuretics on Uric Acid

A

LD/TZ = Hyperuricemia

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12
Q

Loop Diuretic Full AE

A

MCK, GUL

-Hypokalemia, hypocalcemia, hypomagnesemia
-Metabolic Alkalosis
-Hyperuricemia, hyperglycemia, Hyperlipidemia
-Ototoxicity

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13
Q

CAI Full AE

A

-Hypokalemia
-Metabolic Acidosis

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14
Q

Thiazide Diuretic Full AE

A

MK, GULC

-Hypokalemia, hypomagnesemia
-Metabolic Alkalosis
-Hyperglycemia, hyperlipidemia, hypercalcemia, hyperuricemia

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15
Q

K-sparing Full AE

A

-Hyperkalemia
-Metabolic Acidosis

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16
Q

Spironolactone only AE

A

-Hyperkalemia
-Metabolic Acidosis

AND

-Gynecomastia
-Impotence

17
Q

CAI Indications

A

Idiopathic/intracranial HTN, Glaucoma, Acute Mountain Sickness

18
Q

LD Indications

A

Edema, HTN, idio/intra HTN, Hypercalcemia, HFrEF

“HHEC”

19
Q

TZ Indications

A

Edema, HTN, Nephrolithiasis, HFrEF

20
Q

K-sparing Indications

A

Edema, HTN, HFrEF, post-MI

“HHEM”

PPP 2 (16 decks)

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