Antidepressants and Anxiolytics Flashcards
Antidepressants MOA
All increase synaptic availability of monoamines
-TCA: inhibit NET and SERT
-SNRI: inhibit NET and SERT
-SSRI: inhibit SERT
-NDRI: inhibit NET and DAT
AE for increase in NE
NE is A HIT
-Tachycardia
-Hypertension
-Agitation
-Insomnia
AE for increase in 5HT
5 and 3 Ss
-Stomach upset
-Sexual dysfunction
-Serotonin syndrome
-Bleeding
AE for increase in DA
PS duhhh
-Psychosis
-Risk of seizures
AE for MACHR antagonism
-Xerostomia
-Constipation
-Urinary retention
-Confusion
AE for H1 antagonism
Sarah West won (one)
-Weight gain
-Sedation
AE for alpha1 antagonism
-Orthostatic hypotension
Tryptiline, Ipramine
T.I bought an N5 CS
TCAs
MOA: inhibit SERT / NET
AE:
-Increase NE and 5HT
Cardio toxicity
-Highest risk of death in overdose
Not preferred in suicidal pts
Fluoxetine, fluvoxamine, paroxetine, escitalopram, citalopram, sertraline
5CCQ
SSRI
MOA: inhibit SERT
AE:
-Increase 5HT
Lots of CYP interactions
Citalopram: QT prolongation
Fluoxetine is most ___ ; ___ t1/2
Paroxetine; most ___ , ____ t1/2
-Most activating, long t1/2
-Most sedating, short t1/2
Duloxetine, venlafaxine, desvenlafaxine
DVD 5N
SNRI
MOA: inhibit SERT and NET
AE: increase 5HT and NE
BP control
Bupropion
SLND
NDRI
MOA: inhibits DAT and NEET
AE: Increase DA and NE
Does not cause sexual dysfunction
Weight loss/appetite
CI in seizures (BBW)
Mirtazapine
Mir yelled SWS
MOA: alpha2 antagonist, 5TH antagonist
AE:
-sedation
-weight gain
-less sex dysfunction
Trazodone
Traz only needs PSW
MOA: NET, SET, 5HT antagonist
AE:
-sedation
-weight gain
-priapism
Nefazodone
MOA: inhibit NET, SERT, 5HT antagonist
AE:
-sedation
-weight gain
-hepatotoxic
