Chemotherapy 1-9

Question 1

General Adverse Effects of Non-targeted Chemotherapy

Answer 1

-GI: diarrhea, mucositis, nausea, vomiting
-BM: decrease WBC (leukopenia, increase infection risk), decrease platelets (thromebocytopenia, increase bleeding), decrease RBCs (anemia, increase fatigue)
-Hair: alopecia

Question 2

Vincristine

Answer 2

MT NEC “Cristine is from Mt. Nec”

Vinca-alkaloid
MOA: inhibit microtubule polymerization

AE:
-Neurotoxic (peripheral neuropathy)
-Extravasation (monitor for pain/swell/poor blood return)
-Constipation (given with lax/stool softener)

Question 3

Vinblastine

Answer 3

MT HEN “Blast off to Mt. Hen”

Vinca-alkaloid
MOA: inhibit microtubule polymerization

AE:
-Neurotoxic (peripheral neuropathy)
-Extravasation (monitor for pain/swell/poor blood return)
-Hyelotoxic (decreases blasts)

Question 4

Paclitaxel

Answer 4

Pac went to Mt DNA

Taxan
MOA: inhibit microtubule depolymerization

AE:
-Neurotoxic (peripheral neuropathy)
-Anaphylaxis (premed. with steroid and anti-his)

Question 5

Docetaxel

Answer 5

Doc is a MT FAN

Taxan
MOA: inhibit microtubule depolymerization

AE:
-Neurotoxic (peripheral neuropathy)
-Anaphylaxis (premed. with steroid and anti-his)
-Fluid retention (premed. with steroid)

Question 6

6-Mercaptopurine

Answer 6

F HAND

MOA: inhibits de novo purine synthesis

AE: Hepatotoxicity (check LFT)

DDI: Allopurinol, Febuxostat

Question 7

Methotrexate

Answer 7

HB PL

MOA: inhibits de novo purine synthesis and inhibits DHF-reductase / thymidylate synthase

AE:
-Hepatotoxicity (BBW)
-Bone marrow suppression (BBW)

CI: Pregnancy (BBW) - used with misoprostal to end pregnancy

*Leucovorin rescue therapy to limit toxicity

Question 8

5-Fluoruracil (5-FU)

Answer 8

MOA: inhibits thymidylate synthase (prodrug)

AE: hand-foot syndrome (skin toxicity)

Oral prodrug of 5FU = Capecitabine

Question 9

Hydroxyurea

Answer 9

MOA: inhibits ribonucleotide reductase