DRUGS: Naloxone hydrochloride - Narcan

Question 1

Naloxone hydrochloride - Narcan: Class

Answer 1

antidote, opioid antagonist

Question 2

Naloxone hydrochloride - Narcan: Mechanism of Action

Answer 2

receptor inhibitor, reverses respiratory depression caused by opioids, inhibits morphine

Question 3

Naloxone hydrochloride - Narcan: Indications

Answer 3

OD with signs with opioid origin, decreased LOC/coma with ukn origin

Question 4

Naloxone hydrochloride - Narcan: Contraindications

Answer 4

narcotic dependents and neos of dependent mothers

Question 5

Naloxone hydrochloride - Narcan: Adverse Reactions & Side Effects

Answer 5

seizure,
restlessness,
N/V,
diaphoresis,
tachycardia

Question 6

Naloxone hydrochloride - Narcan: Drug Interactions

Answer 6

incompatible with bisulfate and alkaline solutions

Question 7

Naloxone hydrochloride - Narcan: Route

Answer 7

IV, IO, IN, IM-auto

Question 8

Naloxone hydrochloride - Narcan: Dosage and Administration ADULTS

Answer 8

0.4-2.0mg IM/IO/IV, min 2mg max 10mg. IN- half dose per nostril, max 1mL

Question 9

Naloxone hydrochloride - Narcan: Dosage and Administration PEDIATRICS

Answer 9

0.1mg/kg IV/IO/IM every 2min, 2mg max with 0.1mg per kg given after 10m with no response

Question 10

Naloxone hydrochloride - Narcan: Duration of Action

Answer 10

Onset :Less than 2 Minutes
Peak: Varies
Duration: 30-60 Minutes

Question 11

Naloxone hydrochloride - Narcan: Special Considerations

Answer 11

Pregnancy Safety: Category assist vents prior to admin to avoid sympathetic stimulation. Watch for violent behavior in narcotic addicts. Repeat dosing may be needed. Not beneficial in cardiac arrest