Drugs in pregnancy Flashcards
Which drugs don’t cross the placenta?
Heparin
Insulin
Tubocurarine
Which drugs cause abortion?
Misoprostol
Ergometrine
Thrombolytics
What kind of drug is tubocurarine?
An alkaloid used in anaesthetics for muscle relaxation
What is FDA category A?
No fetal risk
What is FDA category B?
No risk in animal studies
No adequate pregnancy studies
What is FDA category C?
Adverse effect in animal studies
No adequate pregnancy data
Benefits outweigh potential risk
What is FDA category D?
Evidence of risk of human teratogenicity
Benefits outweigh potential risk
What is FDA category X?
Evidence of risk of human teratogenicity
Potential risk outweighs benefit
Which structures are predominately effected prior to day 20 due to teratogenic drug exposure?
Limb defects (less than 3 weeks)
Teratogenicity at around day 20 primarily effects which structure?
Brain - leads to anencephaly
approx. 3 weeks
Teratogenic drugs administered at around day 34 effect which structure?
Heart - transposition of the great vessels
approx. 5 weeks
Teratogenic drugs administered at around day 36 effect which structure?
Lips - cleft palate
approx. 5 weeks
Teratogenic drugs administered at around day 42 effect which structure?
Heart and Digits - VSD and syndactyly
6 weeks
Teratogenic drugs administered at around day 84 effect which structure?
penis - hypospadias
12 weeks
Which drugs are not secreted in breast milk?
Warfarin
Aminoglycosides (amikacin/gentamicin)
