Drugs - Hematology Flashcards
Anti-platelet
Aspirin
Clopidogrel
Aspirin class and indications?
NSAID – Analgesic, anti-pyretic, anti-platelet
MI prophylaxis - - Juvenile RA - - Pain and fever (mild to moderate) - - MSK/Joint pain and inflamm. Inhibits cyclooxygense (precursor to synthesis of prostaglandin and thromboxane). Inhibits platelet agg
Aspirin interactions, contraindications, cautions, adverse effects?
2
Clopidogrel class and indications?
Anti-platelet
Platelet aggregation inhibitor
Thromboembolic disorder prophylaxis - - Acute coronary syndrome.
Inhibits ADP from binding to ADP receptors on platelets → prevents activation of glycoprotein GP IIb/IIIa complex thus preventing fibrinogen binding, platelet adhesion, and aggregation.
Clopidogrel interactions, contraindications, cautions, adverse effects?
2
Anticoagulant
Heparin
Warfarin
Heparin class and indications?
Anti-coagulant
DVT - - Pulmonary Embolism - - Arterial thromboembolism - - MI - - Unstable Angina
Injected into vein
Heparin interactions, contraindications, cautions, adverse effects?
2
Vitamin K antagonist
Warfarin
Warfarin class and indications?
Anticoag - Coumarin derivative
Venous thromboembolism prophylaxis.
Inhibits synthesis of Vitamin K dependent coag factors VII, IX, X and II and anticoag protein C and its cofactor protein S. No effects on established thrombus but can prevent extension of clot.
Wafarin interactions, contraindications, cautions, adverse effects?
2