Drugs - Hematology

Question 1

Anti-platelet

Answer 1

Aspirin

Clopidogrel

Question 2

Aspirin class and indications?

Answer 2

NSAID – Analgesic, anti-pyretic, anti-platelet

MI prophylaxis - - Juvenile RA - - Pain and fever (mild to moderate) - - MSK/Joint pain and inflamm. Inhibits cyclooxygense (precursor to synthesis of prostaglandin and thromboxane). Inhibits platelet agg

Question 3

Aspirin interactions, contraindications, cautions, adverse effects?

Answer 3

2

Question 4

Clopidogrel class and indications?

Answer 4

Anti-platelet
Platelet aggregation inhibitor

Thromboembolic disorder prophylaxis - - Acute coronary syndrome.
Inhibits ADP from binding to ADP receptors on platelets → prevents activation of glycoprotein GP IIb/IIIa complex thus preventing fibrinogen binding, platelet adhesion, and aggregation.

Question 5

Clopidogrel interactions, contraindications, cautions, adverse effects?

Answer 5

2

Question 6

Anticoagulant

Answer 6

Heparin

Warfarin

Question 7

Heparin class and indications?

Answer 7

Anti-coagulant

DVT - - Pulmonary Embolism - - Arterial thromboembolism - - MI - - Unstable Angina
Injected into vein

Question 8

Heparin interactions, contraindications, cautions, adverse effects?

Answer 8

2

Question 9

Vitamin K antagonist

Answer 9

Warfarin

Question 10

Warfarin class and indications?

Answer 10

Anticoag - Coumarin derivative

Venous thromboembolism prophylaxis.
Inhibits synthesis of Vitamin K dependent coag factors VII, IX, X and II and anticoag protein C and its cofactor protein S. No effects on established thrombus but can prevent extension of clot.

Question 11

Wafarin interactions, contraindications, cautions, adverse effects?

Answer 11

2