drugs for somwthing else idek

Question 1

drug for OP

Answer 1

bisphosphonates

Question 2

bisphosphonates mechanism of action

Answer 2

binds to hydroxyapatite crystals, osteoclasts consume them. inhibits osteoclasts activity, affects signalling between osteoblasts and osteoclasts

Question 3

bisphosphonates half-life in circulation and body

Answer 3

circulation - 0.5-2 hours
body - several years

Question 4

what other than op can bisphosphonates treat

Answer 4

cancer-induced bone pain and hypercalcaemia
Pagets disease of the bone

Question 5

bisphosphonates adverse affect

Answer 5

oesophageal inflammation
osteonecrosis of jaw

Question 6

drug interactions bisphosphonates

Answer 6

any other drugs causing inflammation of oesophagus - NSAIDs - should be avoided

Question 7

advice for bisphosphonates

Answer 7

empty stomach before breakfast with water.
stay upright for 30 mins after

Question 8

oestrogen-replacement therapy use?

Answer 8

reduce osteoporosis

Question 9

oestrogen mechanism of action

Answer 9

inhibits bone resorption by osteoclasts

Question 10

adverse effects of oestrogen-replacement therapy

Answer 10

endometrial and breast cancer risk
venous thromboembolism
stroke
heart attacks