anti-inflammatory drugs Flashcards

1
Q

4 clinical features of inflammation

A

heat
redness
swelling
pain

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2
Q

what do nsaids inhibit

A

cyclo-oxygenase (COX)

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3
Q

what is aspirin, what’s it used for

A

NSAID. acute management of cardiovascular events (MI, stroke) secondary prevention of cardiovascular disease

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4
Q

adverse effects of NSAIDs

A

gastrotoxicity
asthma exacerbation (attack)
hypertension, oedema, increased cardiovascular risk

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5
Q

corticosteroids examples

A

hydrocortisone (injections), prednisolone (tablet)

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6
Q

which corticosteroid used in inhalers

A

prednisolone

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7
Q

corticosteroids mechanism of action

A

DNA interaction

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8
Q

half life of prednisolone

A

2-3 hrs

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9
Q

time for peak plasma conc for prednisolone

A

1-2 hrs

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10
Q

clinical effects of corticosteroids

A

anti-inflammatory, immunosuppression

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11
Q

clinical indications of corticosteroids

A

often used in emergencies. asthma, COPD,

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12
Q

adverse effects of corticosteroids

A

susceptibility to infections, diabetes, muscle wasting, osteoporosis, growth suppression, wound suppression, psychosis, hypokalaemia, hypertension

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