anti-inflammatory drugs

Question 1

4 clinical features of inflammation

Answer 1

heat
redness
swelling
pain

Question 2

what do nsaids inhibit

Answer 2

cyclo-oxygenase (COX)

Question 3

what is aspirin, what’s it used for

Answer 3

NSAID. acute management of cardiovascular events (MI, stroke) secondary prevention of cardiovascular disease

Question 4

adverse effects of NSAIDs

Answer 4

gastrotoxicity
asthma exacerbation (attack)
hypertension, oedema, increased cardiovascular risk

Question 5

corticosteroids examples

Answer 5

hydrocortisone (injections), prednisolone (tablet)

Question 6

which corticosteroid used in inhalers

Answer 6

prednisolone

Question 7

corticosteroids mechanism of action

Answer 7

DNA interaction

Question 8

half life of prednisolone

Answer 8

2-3 hrs

Question 9

time for peak plasma conc for prednisolone

Answer 9

1-2 hrs

Question 10

clinical effects of corticosteroids

Answer 10

anti-inflammatory, immunosuppression

Question 11

clinical indications of corticosteroids

Answer 11

often used in emergencies. asthma, COPD,

Question 12

adverse effects of corticosteroids

Answer 12

susceptibility to infections, diabetes, muscle wasting, osteoporosis, growth suppression, wound suppression, psychosis, hypokalaemia, hypertension