anti-inflammatory drugs Flashcards
4 clinical features of inflammation
heat
redness
swelling
pain
what do nsaids inhibit
cyclo-oxygenase (COX)
what is aspirin, what’s it used for
NSAID. acute management of cardiovascular events (MI, stroke) secondary prevention of cardiovascular disease
adverse effects of NSAIDs
gastrotoxicity
asthma exacerbation (attack)
hypertension, oedema, increased cardiovascular risk
corticosteroids examples
hydrocortisone (injections), prednisolone (tablet)
which corticosteroid used in inhalers
prednisolone
corticosteroids mechanism of action
DNA interaction
half life of prednisolone
2-3 hrs
time for peak plasma conc for prednisolone
1-2 hrs
clinical effects of corticosteroids
anti-inflammatory, immunosuppression
clinical indications of corticosteroids
often used in emergencies. asthma, COPD,
adverse effects of corticosteroids
susceptibility to infections, diabetes, muscle wasting, osteoporosis, growth suppression, wound suppression, psychosis, hypokalaemia, hypertension