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Pharmacology > Drugs for Parkinsonism > Flashcards

Drugs for Parkinsonism Flashcards

0
Q

Enzyme that converts tyrosine to DOPA

A

Tyrosine hydrogenase

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1
Q

Amino acid precursor of dopamine

A

Tyrosine

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2
Q

Which can cross the BBB? (DOPA/Dopamine)

A

Dopa

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3
Q

Enzyme that converts DOPA to Dopamine

A

DDC (Dopa decarboxylase)

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4
Q

Drug that is co-administered with levodopa because it inhibits Dopa decarboxylase

A

Carbidopa

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5
Q

Peripheral enzymes acting on DOPA

A

DDC (Dopa decarboxylase)

COMT (Catechol-o-methyl transferase)

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6
Q

Drugs that inhibit COMT, therefore increasing DOPA

A

Entacapone

Tolcapone

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7
Q

Drug of choice for Parkinsonism

A

Levidopa

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8
Q

Levodopa ADRs

A

(Pusong Bato)
Insomnia, Psychosis
Cardiovascular
GI disturbances

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9
Q

Parkinson’s disease manifestation

A

Tremors
Bradykinesia
Gait instability
Mask-like appearance

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10
Q

Parkinsonism involves imbalance with what neurotransmitters

A

Dopamine (decreased)

Acetylcholine (increased)

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11
Q

The prototype d2 agonist

A

Bromocriptine

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12
Q

Anti-parkinsonism drug that is also an anti-viral

A

Amantadine

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13
Q

Amantadine’s MOA as antiviral

A

“Manang si Amanda”

It prevents uncoating

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14
Q

Amantadine is mainly used for what virus?

A

Influenza a virus

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15
Q

Drugs that correct imbalance of acetylcholine and dopamine in Parkinsonism

A

L - levodopa
A - anticholinergics (benztropine, orphenadrine, biperiden)
B - bromocriptine, apomorphine, pergolide, pramipexole ropinirole
A - amantadine
S - selegiline

16
Q

Bromocriptine

A

Prototype d2 agonist. Mimic activity of dopamine.

17
Q

Selegiline

A

MAO-B selective inhibitor

18
Q

Neurotransmitters degraded by MAO-B

A

Dopamine only

19
Q

Neurotransmitters degraded by MAO-A

A

Dopamine, Norepinephrine, Serotonin (the monoamine neurotransmitters)

20
Q

Aside for its antiviral and anti-parkinsonism, this drug can be also used for the treatment of EPS induced by anti-psychotics

A

Amantadine

21
Q

Dopamine is also known as

A

Prolactin inhibitor

22
Q

This ADR has been noted on patients taking Amantadine and Bromocriptine

A

Livedo reticularis (mottling of the skin)

Pharmacology (6 decks)

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