Drugs for Parkinsonism Flashcards
Enzyme that converts tyrosine to DOPA
Tyrosine hydrogenase
Amino acid precursor of dopamine
Tyrosine
Which can cross the BBB? (DOPA/Dopamine)
Dopa
Enzyme that converts DOPA to Dopamine
DDC (Dopa decarboxylase)
Drug that is co-administered with levodopa because it inhibits Dopa decarboxylase
Carbidopa
Peripheral enzymes acting on DOPA
DDC (Dopa decarboxylase)
COMT (Catechol-o-methyl transferase)
Drugs that inhibit COMT, therefore increasing DOPA
Entacapone
Tolcapone
Drug of choice for Parkinsonism
Levidopa
Levodopa ADRs
(Pusong Bato)
Insomnia, Psychosis
Cardiovascular
GI disturbances
Parkinson’s disease manifestation
Tremors
Bradykinesia
Gait instability
Mask-like appearance
Parkinsonism involves imbalance with what neurotransmitters
Dopamine (decreased)
Acetylcholine (increased)
The prototype d2 agonist
Bromocriptine
Anti-parkinsonism drug that is also an anti-viral
Amantadine
Amantadine’s MOA as antiviral
“Manang si Amanda”
It prevents uncoating
Amantadine is mainly used for what virus?
Influenza a virus
Drugs that correct imbalance of acetylcholine and dopamine in Parkinsonism
L - levodopa
A - anticholinergics (benztropine, orphenadrine, biperiden)
B - bromocriptine, apomorphine, pergolide, pramipexole ropinirole
A - amantadine
S - selegiline
Bromocriptine
Prototype d2 agonist. Mimic activity of dopamine.
Selegiline
MAO-B selective inhibitor
Neurotransmitters degraded by MAO-B
Dopamine only
Neurotransmitters degraded by MAO-A
Dopamine, Norepinephrine, Serotonin (the monoamine neurotransmitters)
Aside for its antiviral and anti-parkinsonism, this drug can be also used for the treatment of EPS induced by anti-psychotics
Amantadine
Dopamine is also known as
Prolactin inhibitor
This ADR has been noted on patients taking Amantadine and Bromocriptine
Livedo reticularis (mottling of the skin)
