CNS General and Histamine

Question 0

Major inhibitory neurotransmitter

Answer 0

GABA (Gamma-aminobutyric acid)

Question 1

Major excitatory neurotransmitter

Answer 1

Glutamate

Question 2

Serotonin is also known as?

Answer 2

5-HT (5-hydroxytryptamine)

Question 3

Serotonin main function

Answer 3

Mood control

Question 4

GABA that is ionotropic

Answer 4

GABA A

Question 5

GABA that is metabotropic

Answer 5

GABA B

Question 6

GABA A is coupled with what ion channel?

Answer 6

Cl

Question 7

GABA A induces what action potential?

Answer 7

Repolarization/Hyperpolarization

Question 8

Dopamine is also known as

Answer 8

Prolactin inhibitor

Question 9

Pathways of Dopamine

Answer 9

Mesolimbic
Mesocortical
Tuberoinfundibular
Nigrostriatal

Question 10

Dopamine in the nigrostriatal pathway controls what?

Answer 10

Motor control

Question 11

Dopamine through mesolimbic and mesocortical pathways control what?

Answer 11

Thought processes/behavior

Question 12

Dopamine through the tuberoinfundibular controls what?

Answer 12

Prolactin inhibition

Question 13

Norepinephrine functions

Answer 13

Central blood pressure regulation

Arousal and mood

Question 14

Acetylcholine CNS functions

Answer 14

Motor control

Memory

Question 15

Histamine activities

Answer 15

Wakefulness (CNS)
Vasodilation (blood vessels)
Bronchoconstriction (bronchioles)
Parietal cell activation

Question 16

HCl in stomach is released by?

Answer 16

Parietal cells

Question 17

What are the 3 activators of parietal cells?

Answer 17

HKAtpase (proton pump)
M3 receptor (cholinergic activation)
Histamine 2

Question 18

Parietal cells release?

Answer 18

HCl in stomach

Question 19

Histamine that activates parietal cells

Answer 19

Histamine 2

Question 20

Histamine 1 functions

Answer 20

Allergy responses

Question 21

Histamine is mediated by what immunoglobulin?

Answer 21

IgE

Question 22

Histamine are released by?

Answer 22

Mast cells

Question 23

Amino acid precursor of Norepinephrine and Epinephrine

Answer 23

Tyrosine

Question 24

Amino acid precursor of Serotonin

Answer 24

Tryptophan

Question 25

Monoamine neurotansmitters

Answer 25

Dopamine
Norepinephrine
Serotonin

Question 26

Difference between H1 and H2

Answer 26

H1 - allergy responses

H2 - HCl production

Question 27

What generation of H1 blockers can cross the BBB?

Answer 27

1st generation

Question 28

Diphenhydramine

Answer 28

H1 blocker, 1st gen

Question 29

Chlorphenamine

Answer 29

H1 blocker, 1st gen

Question 30

Bromphenamine

Answer 30

H1 blocker, 1st gen

Question 31

Hydroxyzine

Answer 31

H1 blocker, 1st gen

Question 32

Meclizine, cyclizine

Answer 32

H1 blocker, 1st gen

Question 33

Brand name of Hydroxyzine

Answer 33

Iterax

Question 34

Iterax

Answer 34

Hydroxyzine

Question 35

2nd gen H1 blockers

Answer 35

Loratadine
Desloratadine
Cetirizine
Fexofenadine

Question 36

Claritin

Answer 36

Loratadine

Question 37

Clarinex

Answer 37

Desloratadine

Question 38

Allegra

Answer 38

Fexofenadine

Question 39

Zyrtec

Answer 39

Cetirizine

Question 40

H1 blockers uses

Answer 40

Allergy
Insomnia
Anti-emetic and motion sickness

Question 41

Neurotransmitter that has input in vomiting center

Answer 41

Histamine

Question 42

Vomiting center in the brain is known as

Answer 42

Chemoreceptor trigger zone

Question 43

ADR seen most with H1 blockers, 1st gen

Answer 43

Sedation and somnolence

Question 44

Aspartate

Answer 44

Excitatory neurotransmitter