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Pharmacology > Anti-depressants / Mood Stabilizers > Flashcards

Anti-depressants / Mood Stabilizers Flashcards

0
Q

Lithium has (narrow/wide) therapeutic index

A

Narrow

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1
Q

Drug of choice for bipolar disorder aka mania

A

Lithium carbonate or Lithium citrate

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2
Q

If patient has hyponatremia, lithium intracellular levels would (increase/decrease)

A

Increase

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3
Q

MAO inhibitors given with Tyramine-rich foods will result to what ADR

A

Hypertensive crisis

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4
Q

What are examples of tyramine-rich foods?

A

Wine, cheese, chicken liver

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5
Q

MAO B selective inhibitor

A

Selegiline

Deprenyl

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6
Q

MAO B acts on what neurotransmitter

A

Dopamine only

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7
Q

MAO A acts on what neurotransmitter

A

Dopamine
Norepinephrine
Serotonin

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8
Q

MAO A selective inhibitor

A

Moclobemide

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9
Q

MAO nonselective inhibitors

A

Phenelzine
Isocarboxazid
Tranylcypromine

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10
Q

What is Deprenyl?

A

It acts like selegeline. MAO B selective inhibitor.

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11
Q

Most used group of drugs for depression

A

SSRI & SNRI

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12
Q

MOA of SSRI

A

Blocks serotonin reuptake therefore increasing serotonin in synapse

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13
Q

MOA of SNRI

A

Blocks serotonin and norepinephrine reuptake therefore increasing their levels in the synapse

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14
Q

ADR most associated with SSRI

A

Orthostatic hypotension

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15
Q

ADR most associated with SNRI

A

Hypertension

16
Q

-XETINE *except yung dulo (duloxetine) and Citalopram

A

SSRI drugs

17
Q

Duloxetine

A

SNRI

18
Q

ADR seen with all of the Antidepressants

A 
Sexual dysfunction (highest in MAOIs)
Weight gain
19
Q

Antidepressant categories according to MOA

A 
SSRI
SNRI
MAOI
TCA
5HT Ia antagonists
20
Q

-ZODONE

A

5HT Ia antagonists

21
Q

Inhibition of 5HT Ia leads to?

A

Increase of 5HT because 5HT Ia is inhibitory in nature

22
Q

ADR most common with 5HT Ia antagonists

A

Hepatotoxicity

23
Q

MOA of TCAs

A

SNRI-like but also blocks alpha 1, muscarinic, and histamine therefore it has many ADRs

24
Q

-TRIPTYLINE and -PRAMINE

A

TCAs

25
Q

Most severe ADR with TCAs

A

Cardiotoxicity

26
Q

SSRI drugs

A

Sertraline
Fluoxetine
Fluvoxamine
Paroxetine

27
Q

Anti-depressants also used for OCD, Anxiety disorders, and mgt of phobia

A

SSRI and SNRI

28
Q

2nd gen Antidepressants

A

Trazodone
Bupropion
Amoxapine
Maprotiline

29
Q

3rd gen Antidepressants

A

Venlafaxine
Mirtazapine
Nefazodone

30
Q

Second line antidepressants that are more commonly employed as anticonvulsants

A

Valproic acid

Carbamazepine

31
Q

Valproic acid is an (inducer/inhibitor) of CYP 450

A

Inhibitor

32
Q

Carbamazepine is an (inducer/inhibitor) of CYP 450

A

Inducer

Pharmacology (6 decks)

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