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Pharmacology > Anti-psychotics > Flashcards

Anti-psychotics Flashcards

0
Q

Psychosis is defined as?

A

Distortion of reality (delusions, hallucinations, confusion, and impaired memory)

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1
Q

Psychosis is (excess/deficiency) of dopamine

A

Excess

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2
Q

One of the psychiatric illnesses manifesting with psychosis

A

Schizophrenia

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3
Q

In psychosis, there is excess dopamine in what pathways?

A

Mesolimbic and mesocortical

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4
Q

Dopamine through the mesolimbic and mesocortical pathways functions as?

A

Thought and Behavior control

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5
Q

Neurotransmitters associated with Schizophrenia

A

Dopamine
Serotonin
Norepinephrine
Glutamate

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6
Q

Antipsychotics are grouped into

A

Typical and Atypical

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7
Q

-AZINE

A

Phenothiazine typical antipsychotics

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8
Q

-AZINE with PRO

A

Alipathic phenothiazines typical anti-psychotics

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9
Q

-THIXENE

A

Thioxanthenes typical antipsychotics

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10
Q

-APINE

A

Atypical antipsychotics

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11
Q

-PERIDOL

A

Butyrophenones typical antipsychotics

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12
Q

Molindone

A

Typical antipsychotic

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13
Q

How many receptors does dopamine have?

A

5 (D1-D5)

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14
Q

Antipsychotics tend to block what dopamine receptor?

A

D2

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15
Q

Major ADR associated with antipsychotics because of nigrostriatal pathway blockages

A

EPS (Extra Pyramidal Symptoms)

16
Q

EPS Manifestations

A

Parkinsonism-like

Tremors, Ataxia, Bradykinesia

17
Q

Irreversible EPS that when observed, antipsychotics should be stopped immediately

A

Tardive Dyskinesia (circum oral twitching, oculogyric spasm)

18
Q

ADR of Antipsychotics because of tuberoinfundibular dopamine blockage

A

Hyperprolactinemia

19
Q

Unique idiosyncratic reaction ADR with Antipsychotics

A

Neuroleptic Malignant Syndrome

20
Q

Neuroleptic malignant syndrome is mostly reported with what drug?

A

Chlopromazine

21
Q

Neuroleptic analgesia is achieved by what combination of drugs?

A

Droperidol and Opioid analgesic

22
Q

First atypical antipsychotic drug

A

Clozapine

23
Q

Fatal ADR of Clozapine

A

Agranulocytosis

24
Q

Antipsychotics with highest report of hyperprolactinemia

A

Risperidone and paliperidone

25
Q

Most potent antipsychotics

A

Haloperidol and the Piperazine phenothiazines

26
Q

Atypical antipsychotics block what neurotransmitters?

A

Dopamine and serotonin

27
Q

Aside from anti-psychosis, Promethazine has also what activities?

A

Anti-histaminic and anti-emetic

28
Q

Antipsychotic that can cause blindness

A

Thioridazine

29
Q

Advantage of Atypical over Typical antipsychotics

A

Less EPS and more effective on negative symptoms of schizophrenia

30
Q

Positive symptoms of schizophrenia

A

Delusions, Hallucinations, Combativeness, Insomnia

31
Q

Negative symptoms of Schizophrenia

A

The 5 A’s (Affective flattening, Alogia, Avolition-apathy, Anhedonia, Attention deficit)

Pharmacology (6 decks)

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