Anti-psychotics

Question 0

Psychosis is defined as?

Answer 0

Distortion of reality (delusions, hallucinations, confusion, and impaired memory)

Question 1

Psychosis is (excess/deficiency) of dopamine

Answer 1

Excess

Question 2

One of the psychiatric illnesses manifesting with psychosis

Answer 2

Schizophrenia

Question 3

In psychosis, there is excess dopamine in what pathways?

Answer 3

Mesolimbic and mesocortical

Question 4

Dopamine through the mesolimbic and mesocortical pathways functions as?

Answer 4

Thought and Behavior control

Question 5

Neurotransmitters associated with Schizophrenia

Answer 5

Dopamine
Serotonin
Norepinephrine
Glutamate

Question 6

Antipsychotics are grouped into

Answer 6

Typical and Atypical

Question 7

-AZINE

Answer 7

Phenothiazine typical antipsychotics

Question 8

-AZINE with PRO

Answer 8

Alipathic phenothiazines typical anti-psychotics

Question 9

-THIXENE

Answer 9

Thioxanthenes typical antipsychotics

Question 10

-APINE

Answer 10

Atypical antipsychotics

Question 11

-PERIDOL

Answer 11

Butyrophenones typical antipsychotics

Question 12

Molindone

Answer 12

Typical antipsychotic

Question 13

How many receptors does dopamine have?

Answer 13

5 (D1-D5)

Question 14

Antipsychotics tend to block what dopamine receptor?

Answer 14

D2

Question 15

Major ADR associated with antipsychotics because of nigrostriatal pathway blockages

Answer 15

EPS (Extra Pyramidal Symptoms)

Question 16

EPS Manifestations

Answer 16

Parkinsonism-like

Tremors, Ataxia, Bradykinesia

Question 17

Irreversible EPS that when observed, antipsychotics should be stopped immediately

Answer 17

Tardive Dyskinesia (circum oral twitching, oculogyric spasm)

Question 18

ADR of Antipsychotics because of tuberoinfundibular dopamine blockage

Answer 18

Hyperprolactinemia

Question 19

Unique idiosyncratic reaction ADR with Antipsychotics

Answer 19

Neuroleptic Malignant Syndrome

Question 20

Neuroleptic malignant syndrome is mostly reported with what drug?

Answer 20

Chlopromazine

Question 21

Neuroleptic analgesia is achieved by what combination of drugs?

Answer 21

Droperidol and Opioid analgesic

Question 22

First atypical antipsychotic drug

Answer 22

Clozapine

Question 23

Fatal ADR of Clozapine

Answer 23

Agranulocytosis

Question 24

Antipsychotics with highest report of hyperprolactinemia

Answer 24

Risperidone and paliperidone

Question 25

Most potent antipsychotics

Answer 25

Haloperidol and the Piperazine phenothiazines

Question 26

Atypical antipsychotics block what neurotransmitters?

Answer 26

Dopamine and serotonin

Question 27

Aside from anti-psychosis, Promethazine has also what activities?

Answer 27

Anti-histaminic and anti-emetic

Question 28

Antipsychotic that can cause blindness

Answer 28

Thioridazine

Question 29

Advantage of Atypical over Typical antipsychotics

Answer 29

Less EPS and more effective on negative symptoms of schizophrenia

Question 30

Positive symptoms of schizophrenia

Answer 30

Delusions, Hallucinations, Combativeness, Insomnia

Question 31

Negative symptoms of Schizophrenia

Answer 31

The 5 A’s (Affective flattening, Alogia, Avolition-apathy, Anhedonia, Attention deficit)