Drugs for osteo arthritis

Question 1

Drugs for Osteoarthritis

Answer 1

Acetaminophen
NSAIDs
Duloxetine
Tramadol: Inhibitor of Norepi and serotinin uptake
Opioids
Capsaicin
Intraarticular Corticoids

Question 2

• First line Tx. for mild to moderate osteoarthritic pain w/out signs and symptoms of inflammation.
• clinically no anti-inflammatory activity
• fewer side effects

Answer 2

Acetaminophen

Question 3

NSAID

Diclofenac

Answer 3

available topical gel or solution for local tx. of osteoarthritis.

Question 4

Duloxetine

Answer 4

Selective serotonin and norepinephrine reuptake inhibitor.

- Approved for chronic musculoskeletal pain

Question 5

Tramadol

Answer 5

Approved for Tx of moderate to moderately severe chronic pain in adults.

Question 6

Capsaicin

Answer 6

• Topical application of capsaicin reduces osteoarthric pain in some patients.
• It can cause severe skin burns and nerve damage at the site of application
• The dried residue can cause coughing sneezing and eye irritation

Question 7

Intraarticular glucucorticoid injections are used with persistent symptoms in one or a few affected joints. What 2 drugs are commonly used?

Answer 7

Betamethasone and Triamcinolone

Question 8

OPIOIDS

Answer 8

• Last resort for treatment of intractable osteoarthritis pain.
• Agents used include hydrocodone, morphine, and oxycodone.