Adrenergic Drugs

Question 1

Direct acting adrenergic agonists: Endogenous Catecholamines [and D1 agonists]

Answer 1

Epinephrine
norepinephrine
dopamine

Question 2

Epinephrine: Metabolic effects

Answer 2

• Increased Glycogenolysis due to beta 2 effects

- Increased Lipolysis (Beta 3 effects)

Question 3

Uses of epinephrine

Answer 3

• Anaphylactic shock (drug of choice)
• Asthma attacks
• Cardiac arrest: can restore norma rhythm back to heart
• In local anesthetics: increases duration of anesthesia by causing vasoconstriction at the site of injection

Question 4

Norepinephrine

Answer 4

Potent agonist at a1, a2 & B1 receptors

- little action at B2 receptors

Question 5

Effects of Atropine pretreatment before norepinephrine causes..

Answer 5

Tachycardia

Question 6

Norepinephrine use:

Answer 6

Used to treat shock because it increases vascular resistance and therefore increases bp
- dopamine is better

Question 7

low, intermediate and high dopamine effects: Cardiovascular actions

Answer 7

low: Increased GFR, increased sodium excretion, vasodilation, increased renal blood flow.

Intermediate: B1 receptors in heart and increased cardiovascular output, MAP is increased, PVR unchanged or slightly decreased

High: a1 causing vasoconstriction, increased total peripheral resistance

Question 8

Dopamine

Answer 8

• Used for Severe cardiac heart failure

- used for cardiogenic and septic shock

Question 9

Beta- phenylethylamine

Answer 9

parent compound of the sympathomimetic drugs.