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Pharmacology > Drugs And Kidney > Flashcards

Drugs And Kidney Flashcards

0
Q

How do diuretics help hypertension

A

Decrease blood vol, decrease pressure on blood vessels, decrease blood pressure

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1
Q

What is a diuretic

A

Drug that increases the amount of fluid and salts excreted by the kidney and also decrease blood vol

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2
Q

How are salts moved

A

Active transport and passive transport

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3
Q

What are the 3 pumps in the kidney

A

N/K, Na/Cl, Na/Cl/K

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4
Q

Where do thiazides act

A

Distal convoluted tubule

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5
Q

Bendroflumethazide

A

Thiazide diuretics

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6
Q

Metolazone

A

Thiazide diuretics

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7
Q

Indapamide

A

Thiazide diuretics

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8
Q

Action of thiazides

A

Block the Cl pump so increase the excretion of Na and Cl. Can’t be reabsorbed so neither can water

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9
Q

How long do thiazide diuretics work

A

Up to 24 hours and act within 1-2 hours

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10
Q

Side effects of thiazides

A

Hypokalemia, hypocalcemia, hyperuricemia, hyperglycemia

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11
Q

Cation of loop diuretics

A

On the ascending loop of henle, stop the Na, Cl, k pump to increase urine excretion

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12
Q

Furosemide

A

Loop diuretic

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13
Q

Bumetadine

A

Loop diuretic

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14
Q

How long do they work for

A

Act within an hour for up to 6,very powerful from 1ml a min to 8

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15
Q

Loop diuretic side effects

A

Hypocalcemia, hypokalemia, hyperuricemia, hyperglycemia, deafness.

16
Q

Potassium sparing diuretic action

A

Act on late distal tubule and the collecting duct increase the secretion of everything else bar k

17
Q

Spironolactone

A

Potassium sparing diuretic

18
Q

Eplerenone

A

Potassium sparing diuretic

19
Q

Amiloride

A

Potassium sparing diuretic

20
Q

How quick potassium sparing work

A

Weakest of the three

21
Q

Side effect of Potassium sparing diuretic

A

Hyperkalaemia, need to monitor electrolyte

Levels

22
Q

Action of anti diuretics

A

Collecting tubule, increase the number of aqua poring by v2 receptors

23
Q

Vasopressin

A

Anti diuretic

24
Q

Desmopressin

A

Anti diuretic

25
Q

How long anti diuretics work

A

Vasopressin is short and IV only and increases bp, des so is longer taken orally and doesn’t affect the bp.

Pharmacology (9 decks)

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