Asthma Treatments Flashcards

0
Q

Triggers

A

Exposure to allergens, emotion, diet, cold air, exercise, pollutants, drugs (aspirin and beta blockers)

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1
Q

What is asthma

A

Airway hyper responsiveness, limitation and inflammation of the bronchioles

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2
Q

Salbutamol

A

Bronchodilator

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3
Q

Salmeterol

A

Bronchodilator (long lasting)

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4
Q

Ipratropium

A

Block m receptors Bronchodilator stops mucus secretion

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5
Q

Theophylline

A

Bronchodilator

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6
Q

Action of bronchodilator

A

Relaxes smooth muscles of the bronchioles and widens the airways

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7
Q

Where are alpha 1

A

Blood vessels

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8
Q

Where are alpha 2

A

Medulla oblong area

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9
Q

Where are B1

A

Heart

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10
Q

Where are B2

A

Lungs

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11
Q

Beclometasone

A

Prevent the anti inflam response

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12
Q

Sodium cromoglicate

A

Prevent the anti inflam response

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13
Q

Montelukast

A

Prevent the anti inflam response

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14
Q

B2 agonist side effects

A

Tremor, increase HR

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15
Q

How much of inhaler reaches lungs

A

If used properly, 50% in mouth 10% in lungs

16
Q

Action of the steroid based treament

A

Reduce mucus secretion, cross the cell membrane as are lipid soluble and change the protein production so take a few days to work

17
Q

Side effects of inhaled glucocorticoid steroids

A

Oral Candida albicans

18
Q

Oral prednisolone

A

Steroid for acute asthma attack

19
Q

Action of antimuscarinic bronchodilators

A

Block m receptors to inhibit bronchoconstriction

20
Q

Action of cromones

A

Inhibit the release of histamines from mast cells, useful for when exercising

21
Q

Nedocromil sodium

A

Cromone

22
Q

Sodium cromoglicate

A

Cromone

23
Q

Action of LeUKotriene receptor AntagoniSts

A

Stop the release of inflam cells and prevent constriction

24
Q

Montelukast

A

LeUKotriene receptor AntagoniSts

25
Q

Zafirlukast

A

LeUKotriene receptor AntagoniSts

26
Q

What’s good about LeUKotriene receptor AntagoniSts

A

Good for children that can’t take steroids

27
Q

Theophylline

A

Oral taken with b2 agonists or steroids, they block and enzyme PDE that causes the muscles to relax

28
Q

Omalizumab

A

Antibody injected to prevent allergic asthma but very expensive

29
Q

Treatment strategy for asthma

A
  1. Inhaled short term B 2 agonist
  2. Inhaled steroids
  3. Long lasting inhaled B2 agonist + increased dose of inhaled steroid
  4. Short and long B2 + inhaled steroid+ other e.g. ltr
  5. Oral steroids and immunosupressents