Asthma Treatments Flashcards

0
Q

Triggers

A

Exposure to allergens, emotion, diet, cold air, exercise, pollutants, drugs (aspirin and beta blockers)

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1
Q

What is asthma

A

Airway hyper responsiveness, limitation and inflammation of the bronchioles

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2
Q

Salbutamol

A

Bronchodilator

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3
Q

Salmeterol

A

Bronchodilator (long lasting)

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4
Q

Ipratropium

A

Block m receptors Bronchodilator stops mucus secretion

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5
Q

Theophylline

A

Bronchodilator

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6
Q

Action of bronchodilator

A

Relaxes smooth muscles of the bronchioles and widens the airways

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7
Q

Where are alpha 1

A

Blood vessels

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8
Q

Where are alpha 2

A

Medulla oblong area

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9
Q

Where are B1

A

Heart

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10
Q

Where are B2

A

Lungs

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11
Q

Beclometasone

A

Prevent the anti inflam response

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12
Q

Sodium cromoglicate

A

Prevent the anti inflam response

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13
Q

Montelukast

A

Prevent the anti inflam response

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14
Q

B2 agonist side effects

A

Tremor, increase HR

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15
Q

How much of inhaler reaches lungs

A

If used properly, 50% in mouth 10% in lungs

16
Q

Action of the steroid based treament

A

Reduce mucus secretion, cross the cell membrane as are lipid soluble and change the protein production so take a few days to work

17
Q

Side effects of inhaled glucocorticoid steroids

A

Oral Candida albicans

18
Q

Oral prednisolone

A

Steroid for acute asthma attack

19
Q

Action of antimuscarinic bronchodilators

A

Block m receptors to inhibit bronchoconstriction

20
Q

Action of cromones

A

Inhibit the release of histamines from mast cells, useful for when exercising

21
Q

Nedocromil sodium

22
Q

Sodium cromoglicate

23
Q

Action of LeUKotriene receptor AntagoniSts

A

Stop the release of inflam cells and prevent constriction

24
Montelukast
LeUKotriene receptor AntagoniSts
25
Zafirlukast
LeUKotriene receptor AntagoniSts
26
What's good about LeUKotriene receptor AntagoniSts
Good for children that can't take steroids
27
Theophylline
Oral taken with b2 agonists or steroids, they block and enzyme PDE that causes the muscles to relax
28
Omalizumab
Antibody injected to prevent allergic asthma but very expensive
29
Treatment strategy for asthma
1. Inhaled short term B 2 agonist 2. Inhaled steroids 3. Long lasting inhaled B2 agonist + increased dose of inhaled steroid 4. Short and long B2 + inhaled steroid+ other e.g. ltr 5. Oral steroids and immunosupressents