Drugs affecting the autonomic ganglia Flashcards
What is the neurotransmitter for the autonomic ganglia?
Acetylcholine
What does acetylcholine stimulate in the autonomic ganglia?
Nicotinic neural receptors
Describe the effects of nicotine as a ganglionic stimulant
-Increases the activity of sympathetic and parasympathetic systems
- Increases heart rate, blood pressure and GI activity
Name two types of drugs used in smoking cessation
- ganglion stimulants
- Ganglion blockers
Describe ganglion stimulants
Nicotine containing preparations are used in nicotine replacement therapy
Name two examples of ganglion stimulants
-Bupropion
-Varenicline
Adverse effects of bupropion and varenicline
Bupropion
-dry mouth, insomnia, G.I. disturbances
- neurological effects
Varenicline
- Nausea, vomiting, constipation, headaches
- suicidal ideation
Describe ganglionic blockers
- Bind to nicotine neural receptors
- decrease activity cardiovascular GI and genitourinary system
Adverse effects of ganglionic blockers
Decreased GA activity
Visual disturbances
Decreased cardiovascular and genitourinary function
