Drugs Affecting NT Release

Question 0

Reserpine

Answer 0

Drugs Affecting NT Release
Interferes with biogenic amine uptake and storage.
Not used clinically, Depletion of NE, DA, 5-HT both in the brain and peripherally.
Side effects: severe diarrhea, depression, sedation, parkinson’s like symptoms.

Question 1

Metyrosine

Answer 1

Decrease production of NT

Pheochromocytoma, Tyrosine Hydroxylase inhibitor (Dec. DA/NE in nerves), (Dec E in Adrenal medulla)

Question 2

Guanithidine

Answer 2

Drugs Affecting NT Release
Inihibits NE release from nerve terminal
Not used clinically
Previously used for HTN