Alpha Receptor Blockers

Question 0

Phenoxybenzamine

Answer 0

Alpha Receptor Blockers
Non-Competitive, Irreversible
a1/a2
Effects last several days, Lowers BP
Treatment of pheochromocytoma

Question 1

Phentolamine

Answer 1

Alpha Receptor Blockers
a1/a2
Vasodilator (blocks A1), Inc NE (blocks A2)
Tachycardia, arrhythmia, MI, hypotension side effects
Used in HTN crises

Question 2

Prazosin

Answer 2

Alpha-1 Blocker
a1
3hr half life, 7-10hr duration, Liver metabolized (dec dose in CHF pts)
First dose phenomenon
HTN and BPH

Question 3

Terazosin

Answer 3

Alpha-1 Blocker
a1
Long half life, 12hr action, 1 dose per day
Decrease size of prostate via apoptosis, good for BPH as well as HTN
First dose phenomenon

Question 4

Doxazosin

Answer 4

Alpha-1 Blocker
a1
20 hr half life
Same as terazosin, first dose phenomenon

Question 5

Tamsulosin

Answer 5

Alpha-1 blocker
a1A/1D-will relax base of bladder, sphincter, and prostate-treat BPH
5-10hr half life, metabolized in liver, little effect on BP
Difficulty w/ejaculation

Question 6

Alfuzosin

Answer 6

Alpha-1 blocker
a 1A/1D
Similar to Tasulosin
treat BPH

Question 7

Silodosin

Answer 7

Alpha-1 Blocker
a1A/1D
Similar to Tamsulosin
Treat BPH

Question 8

Yohimibine

Answer 8

Alpha-2 Blocker
a2
Available w/o prescription, Not proven to work, antagonizes effect of clonidine, dangerous in ppl w/HTN