Drugs Across the Lifespan Flashcards
What are the five pharmacokinetic processes
Absorption, protein binding, blodd-brain barrier, hepatic metabolism, renal excretion
What’s different in pediatric absorption
Increased ACIDITY, LIMITED protein binding, BBB not fully developed, SLOW metabolized and excretion
Age 1 and older have faster or slower metabolizim
Faster, then decreased over time
What do glucocorticoids do to peds
Growth suppression
What do tetracyclines do to pediatrics
Discoloration of developing teeth
What does aspirin do to peds
Reye’s syndrome
What determines drug dosage
Body surface
What are the two big issues with older people
Polypharm, increased reactions
What is decreased in old peopl
Absorption, metabolism, excretion, total body water, albumin
How much more likely are older adults likely to have adverse drug reactions, why
SEVEN, drug BUILD UP, POLYPHARM, multiple CONDITIONS, therapeutic WINDOWS
How to reduce ADR’s
Drug HISTORY, consider CHANGES,, MONITOR RESPONSE and INTERACTIONS, SIMPLE drug regimens
What is the nonadherence % and why
75%, cost, forget, side effects
What happens with pregnate women
INCREASED METABOLISM and EXCREATION
When do most gross malfomations happen
Early pregnancy
What type of drugs can easily pass through breast milk and the plecenta
lipid
