Adrenal Flashcards
What do adrenal cortex hormones affect
GLUCOSE, WATER and ELECTROLYTE, SEX characteristics, responses to STRESS
What are the three classes of the steroid hormones produced by the adrenal cortex
GLUCO/MINERALCORTICOIDS, ANDROGENS (SEX hormones)
What is adrenal hormone EXCESS
CUSHING’S syndrome
What is adrenal hormone DEFICIENCY
ADDISON’S disease
What happens at low levels of glucocoticoids
METABOLISM
What do mineralocorticoids do
Influence, RENAL precessing of SODIUM, POTASSIUM, and HYDROGEN, ALDOSTERONE
What does aldosterone do
Promotes sodium and potassium reabsorption
What are the causes of cushing’s syndrome
Hypersecretion of ACTH, and glucocorticoids, and in large DOSES
What is the lcinical presentation of cushing’s syndrome
OBESITY, HYPERGLYCEMIA, GLYCOSURIA, HTN, FLUID and ELCTROLYTE disturbancees
What is the treatments of cushing syndrome
SURGICAL removal, REPLACEMENT therapy with glucocorticoids, KETOCONAZOLE
What is primary hyperaldosteronism
Excessive secretion of ALDOSTERONE
Causes: HypoKALEMIA, ALKALOSISm HTN
Treatment: treat CAUSE, SPIRONOLACTONE
What are the general therapeutic considerations of adrenal hormone insufficiency
REPLACEMENT therapy with GLUCOCORTICOIDS, 2/3 in MORNING, 1/3 in afternoon, DOSAGE increased in STRESS
What is the clinical presentation and cuases of ADDISON’s disease
WEAKNESS, HYPOTENSION, EMACIATION, HYPERKALALEMIA, HYPONATREMIA/GLYCEMIA, increased PIGMENTATION of skin
What is the treatment of adrenal hormone
REPLACEMENT therapy with HYDROCORTISONE
Tell me about adrenal hormone insufficiency
Adrenal secretion of GLUCOCORTICOIDS is diminished, TREAT with hydrocortisone
What can acute adrenal insufficiency (adrenal crisis) lead to
Death
What are the clinical presentations of adrenal hormone insufficiency
Hypotnesion, Dehydration, wekness, lethary, GI issues
What are the causes of adrenal hormone insufficiency
ADRENAL/ PITUITARY failure, inadequate dosease of CORTICOSTEROIDS
What is the treatment of adrenal hormone insufficiency
Rapid replacement of FLUID, SALT, and glucocoritcoids (HYDROCORTISONE), GLUCOSE
What is the primary diagnostic test
ACTH
