Drugs

Question 1

Bromocriptine

Answer 1

Stimulate dopamine receptors; inhibit prolactin secretion; reduce size of prolactinomas; decrease growth hormone concentration in acromegaly

Indications: Parkinsons, acromegaly, hyperprolactinaemia

Safe in pregnancy
Inhibits lactation

Question 2

Pyridostigmine

Answer 2

Reduce breakdown of neuronally released acetylcholine by inhibiting cholinesterase; reduce neuromuscular transmission in skeletal and smooth muscles

Indications: myasthenia gravis

Question 3

Sildenafil

Answer 3

Inhibition of phosphodiesterase 5 (PDE5) leads to relaxation of smooth muscle in the pulmonary vascular bed producing vasodilation and reduction of pulmonary vascular resistance

Indication: Pulmonary arterial hypertension

Question 4

Netupitant

Answer 4

Neurokinin-1 (NK1) receptor antagonist

For chemo related nausea and vomiting

Question 5

Nizatidine

Answer 5

H2 receptor blocker
Works on parietal cells to decrease acid secretion
GORD

Question 6

Pegvisomant

Answer 6

Growth hormone receptor antagonist

Blocks peripheral production of insulin like growth factor

Question 7

Galantamine

Answer 7

Cholinesterase inhibitor

Mild-moderate Alzheimer’s

Question 8

Teriparatide

Answer 8

Recombinant form of the bioactive portion of PTH. In intermittent use it activates osteoblasts more than osteoclasts leading to an overall increase in bone formation.

Question 9

Adexanet Alpha

Answer 9

Recombinant modified human factor Xa decoy protein for the reversal of apixaban and rivaroxaban in patients with uncontrollable bleeding