Antibodies Flashcards
Anti GM-CSF
Pulmonary alveolar proteinosis
Anti-La
Sjogrens
Anti centromere
Limited scleroderma / CREST
Anti-dsDNA
Specific for SLE
Anti-Jo1
Polymyositis
Anti-U1RNP
Mixed connective tissue disease
Anti-Smith
SLE, specific
a/w renal and neurological lupus
Anti-topoisomerase (Anti-SCL70)
Diffuse Scleroderma, associated with ILD
Anti-histone
Drug induced lupus SLE
Anti-CCP
RA, specific
C-ANCA (anti-PR3)
Wegner’s / Granulomatosis with Polyangitis
P-ANCA (anti MPO)
Microscopic Polyangitis,
P-ANCA negative Eosinophilic granulomatosis with Polyangitis
Anti-SRP
Polymyositis - highly aggressive, poor response to immunosuppression
Can also be seen in necrotizing autoimmune myositis
Anti-RNA polymerase III
Scleroderma, a/w renal disease
Anti-Ro60/SSA
Sjogrens
Neonatal lupus erythematous
Subcutaneous cutaneous lupus erythematous (SCLE)
Anti-U3-RNP
Diffuse scleroderma, pulmonary arterial hypertension, myositis
Anti-Th/To
Limited scleroderma
Anti-PM-SCL
Myositis
Anti-La / SSB
Sjogrens
Neonatal lupus erythematous
Anti-synthetase
Anti-synthetase syndrome including ILD, arthritis, fever, Raynaud phenomenon, mechanic’s hands
Anti-Mi-2
Dermatomyositis
Anti-smooth muscle antibody
Primary Biliary Cholangitis
Voltage-gated potassium channel (VGKC)-complex antibodies
Anti-LGI1
Limbic encephalitis, Morvan syndrome (neuromyotonia, memory loss and confusion, sleep disturbances, autonomic instability), neuromyotonia, faciobrachial dystonic seizures
Anti-Caspr2 associated encephalitis
Caspr2 plays a role in maintaining normal role of VgKC
Variable presentation
Anti Purkinje antibody
Anti-Yo antibody
Purkinje cell cytoplasmic antibody Type 1 (PCA-1)
Target are the cerebellar degeneration related proteins that are expressed by Purkinje cells and ovarian and breast cancers
= paraneoplastic cerebellar degeneration
Anti-NMDA
Anti-NMDA receptor encephalitis
Features: prominent psychiatric manifestations, insomnia, memory deficits, seizures, decreased LOC, frequent dyskinesias, autonomic instability, language dysfunction
Anti-aquaporin 4
Neuromyelitis optica spectrum disorders
Disease specific serum NMO-IgG antibody that selectively binds aquaporin-4
Features: acute attacks of bilateral or rapidly sequential optic neuritis (severe visual loss) or transverse myelitis (limb weakness, sensory loss, bladder dysfunction)
Anti-GAD
Glutamic acid decarboxylase
T1DM
Anti-MuSK (muscle specific kinase)
AChR-Ab negative Myasthenia Gravis
Anti-amphiphysin
Stiff-person syndrome
Features: progressive muscle stiffness, rigidity, spasm involving the axial muscles
Caused by increased muscle activity due to decreased inhibition of the CNS that results from blockade of glutamic acid decarboxylase (GAD), an enzyme critical for maintaining inhibitory pathways.
Anti voltage gated calcium channel antibodies (VGCC)
Lambert Eaton Myasthenic Syndrome (LEMS)
Features: slowly progressive proximal muscle weakness
Anti-GM1
Multifocal motor neuropathy
Also elevated in Guillain-Barre
HMG CoA reductase antibodies
Immune mediated necrotizing myopathy secondary to statin use
Anti-MDA5 (melanoma differentiation associated gene 5)
Rapidly progressive Interstitial lung disease
Predominant cutaneous features
A/w dermatomyositis
Anti-SRP
Inflammatory myopathies
Associated with poorer prognosis - severe myopathy and end organ failure
Anti DFS70 association
Positively results means unlikely to be SLE
Dense fine speckled
Anti Hu
Paraneoplastic SCLC and neuroblastoma Painful sensory neuropathy Encephalomyelitis Cerebellar Syndrome
Anti Yo
Paraneoplastic Syndrome
Breast and ovarian cancer
Cerebellar Syndrome
Anti-Ri
Paraneoplastic Syndrome
Breast and SCLC
Occular opsoclonus-myoclonus
Anti-GAD
Breast, colorectal and SCLC
Stiff persons syndrome, hypertonia
