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BPT Written > Antibodies > Flashcards

Antibodies Flashcards

1
Q

Anti GM-CSF

A

Pulmonary alveolar proteinosis

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2
Q

Anti-La

A

Sjogrens

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3
Q

Anti centromere

A

Limited scleroderma / CREST

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4
Q

Anti-dsDNA

A

Specific for SLE

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5
Q

Anti-Jo1

A

Polymyositis

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6
Q

Anti-U1RNP

A

Mixed connective tissue disease

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7
Q

Anti-Smith

A

SLE, specific

a/w renal and neurological lupus

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8
Q

Anti-topoisomerase (Anti-SCL70)

A

Diffuse Scleroderma, associated with ILD

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9
Q

Anti-histone

A

Drug induced lupus SLE

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10
Q

Anti-CCP

A

RA, specific

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11
Q

C-ANCA (anti-PR3)

A

Wegner’s / Granulomatosis with Polyangitis

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12
Q

P-ANCA (anti MPO)

A

Microscopic Polyangitis,

P-ANCA negative Eosinophilic granulomatosis with Polyangitis

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13
Q

Anti-SRP

A

Polymyositis - highly aggressive, poor response to immunosuppression

Can also be seen in necrotizing autoimmune myositis

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14
Q

Anti-RNA polymerase III

A

Scleroderma, a/w renal disease

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15
Q

Anti-Ro60/SSA

A

Sjogrens
Neonatal lupus erythematous
Subcutaneous cutaneous lupus erythematous (SCLE)

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16
Q

Anti-U3-RNP

A

Diffuse scleroderma, pulmonary arterial hypertension, myositis

17
Q

Anti-Th/To

A

Limited scleroderma

18
Q

Anti-PM-SCL

A

Myositis

19
Q

Anti-La / SSB

A

Sjogrens

Neonatal lupus erythematous

20
Q

Anti-synthetase

A

Anti-synthetase syndrome including ILD, arthritis, fever, Raynaud phenomenon, mechanic’s hands

21
Q

Anti-Mi-2

A

Dermatomyositis

22
Q

Anti-smooth muscle antibody

A

Primary Biliary Cholangitis

23
Q

Voltage-gated potassium channel (VGKC)-complex antibodies

A

Anti-LGI1
Limbic encephalitis, Morvan syndrome (neuromyotonia, memory loss and confusion, sleep disturbances, autonomic instability), neuromyotonia, faciobrachial dystonic seizures

Anti-Caspr2 associated encephalitis
Caspr2 plays a role in maintaining normal role of VgKC
Variable presentation

24
Q

Anti Purkinje antibody
Anti-Yo antibody
Purkinje cell cytoplasmic antibody Type 1 (PCA-1)

A

Target are the cerebellar degeneration related proteins that are expressed by Purkinje cells and ovarian and breast cancers
= paraneoplastic cerebellar degeneration

25
Q

Anti-NMDA

A

Anti-NMDA receptor encephalitis
Features: prominent psychiatric manifestations, insomnia, memory deficits, seizures, decreased LOC, frequent dyskinesias, autonomic instability, language dysfunction

26
Q

Anti-aquaporin 4

A

Neuromyelitis optica spectrum disorders

Disease specific serum NMO-IgG antibody that selectively binds aquaporin-4

Features: acute attacks of bilateral or rapidly sequential optic neuritis (severe visual loss) or transverse myelitis (limb weakness, sensory loss, bladder dysfunction)

27
Q

Anti-GAD

A

Glutamic acid decarboxylase

T1DM

28
Q

Anti-MuSK (muscle specific kinase)

A

AChR-Ab negative Myasthenia Gravis

29
Q

Anti-amphiphysin

A

Stiff-person syndrome
Features: progressive muscle stiffness, rigidity, spasm involving the axial muscles

Caused by increased muscle activity due to decreased inhibition of the CNS that results from blockade of glutamic acid decarboxylase (GAD), an enzyme critical for maintaining inhibitory pathways.

30
Q

Anti voltage gated calcium channel antibodies (VGCC)

A

Lambert Eaton Myasthenic Syndrome (LEMS)

Features: slowly progressive proximal muscle weakness

31
Q

Anti-GM1

A

Multifocal motor neuropathy

Also elevated in Guillain-Barre

32
Q

HMG CoA reductase antibodies

A

Immune mediated necrotizing myopathy secondary to statin use

33
Q

Anti-MDA5 (melanoma differentiation associated gene 5)

A

Rapidly progressive Interstitial lung disease
Predominant cutaneous features
A/w dermatomyositis

34
Q

Anti-SRP

A

Inflammatory myopathies

Associated with poorer prognosis - severe myopathy and end organ failure

35
Q

Anti DFS70 association

A

Positively results means unlikely to be SLE

Dense fine speckled

36
Q

Anti Hu

A 
Paraneoplastic 
SCLC and neuroblastoma
Painful sensory neuropathy 
Encephalomyelitis 
Cerebellar Syndrome
37
Q

Anti Yo

A

Paraneoplastic Syndrome
Breast and ovarian cancer
Cerebellar Syndrome

38
Q

Anti-Ri

A

Paraneoplastic Syndrome
Breast and SCLC
Occular opsoclonus-myoclonus

39
Q

Anti-GAD

A

Breast, colorectal and SCLC

Stiff persons syndrome, hypertonia

BPT Written (16 decks)

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