drugs Flashcards
what do doctors call an addictive drug?
if it has the ability to make you dependant on it
what may arise if a drug is taken regularly?
a tolerance
why is tolerance to drugs created?
the brain adapts to higher levels of dopamine caused by the drug causing the regulation of natural production to change
what regulation does tolerance change?
the natural production of dopamine
what area of the brain do addictive drugs activate?
the reward system
what is the reward system?
a pathway of dopamine releasing neurones
what does the reward system include?
the ventral tangent and the nucleus accumbuns
what happens when the reward system is activated?
increases the amount of dopamine being made
pleasurable feeling
what feeling is created that accounts for addiction?
feel pleasure
what are recreational drugs?
drugs that are taken in absence of medical grounds, for personal enjoyment
caffeine nicotine alcohol coke
what is the mode of action of cannabis?
cannabis binds to cannaboid receptors which prevents neurotransmission from the presynaptic N to the post
hippocampus has a lot here so it affects memory
stops neurones from preventing dopamine production in the reward system
more dopamine
which area of the brain has a lot of cannaboid receptors?
the hippocampus
what does cannabis stop?
the neurones that prevent dopamine production
what is the mode of action of amphetamines?
ampetemines force the release of dopamine and also block repute resulting in more dopamine in the synapse
in high doses can inhibit the enzymes that break down dopamine
have a similar stricter to dopamine so can enter the terminal button of presynaptic neurone via dopamine transporters and force the release of dopamine out of storage
can easily act on receptor sights so short term effects
what is amphetamines similar to in structure?
dopamine