Drugs

Question 1

What is the mode of action of topical corticosteroids?

Answer 1

Vasoconstrictive
Anti-inflammatory
Antiproliferative

Question 2

In what conditions are topical steroids used?

Answer 2

Eczema
Psoriasis
Lichen planus
Keloid scars

Question 3

Side effects of topical steroids

Answer 3

Thinning of the skin 
Purpura 
Stretch marks
Steroid rosacea 
Perioral dermatitis 
Fixed telangectasia

Question 4

Examples of antiseptics

Answer 4

Povidone iodine
Chlorhexidine
Triclosan
Hydrogen peroxide

Question 5

Clinical uses of antiseptics

Answer 5

Recurrent infections
Antibiotic resistance
Wound irrigation

Question 6

What conditions can topical antibiotics be used in?

Answer 6

Acne
Rosacea
Impetigo
Infected eczema

Question 7

Which topical antibiotics are effective in acne?

Answer 7

Clindamycin
Erythromycin
Tetracycline

Question 8

Which topical antibiotic is most effect for rosacea?

Answer 8

Metronidazole

Question 9

Which topical antibiotics are used for impetigo?

Answer 9

Mupirocin

Fusidic acid

Question 10

Which skin conditions are given oral rather than topical antiviral?

Answer 10

Eczema herpeticum 
Herpes zoster (shingles)

Question 11

What topical treatment is given for candida?

Answer 11

Antiyeast (e.g. Nystatin, clotrimazole)

Question 12

What topical treatment is give for ringworm?

Answer 12

Antifungal (e.g. clotrimazole, terbinafine cream)

Question 13

Examples of antipuritics

Answer 13

Menthol
Capsaicin
Camphor/phenol

Question 14

In what conditions are keratolytics used?

Answer 14

Viral warts
Hyperkeratotic eczema & psoriasis
Corns & calluses

Question 15

Example of keratolytic

Answer 15

Scalicylic acid

Question 16

What other treatments can emollients be paired with to treat psoriasis?

Answer 16

Coal tar 
Vit D analogues 
Keratolytic 
Topical steroid 
Dithranol

Question 17

What is iquimod?

Answer 17

An immune response modulator (anti-viral, anti-tumour effects)

Question 18

What is imiquimod used to treat?

Answer 18

Genital warts

Superficial BCC

Question 19

Examples of calcineurin inhibitors

Answer 19

Tacrolimus

Pimecrolimus

Question 20

What skin conditions can calicneurin inhibitors be used to treat?

Answer 20

Atopic eczema (topical)

Question 21

What is the purpose of emollients?

Answer 21

To enhance rehydration of epidermis

Question 22

First line management scabies

Answer 22

Permethin

Question 23

First line boy with mild acne

Answer 23

Topical retinoid or benzoyl oeroxide

Question 24

What is the singlemost important barrier to drug penetration?

Answer 24

Stratum corneum

Question 25

What makes up the brick in the “brick & mortar” model of the stratum corneum?

Answer 25

Corneocytes

Question 26

What makes up the mortar in the “brick & mortar” model of the stratum corneum?

Answer 26

multiple bilayers of lamellar structures of intercellular lipids

Question 27

What variants change the glucocorticoid penetrance?

Answer 27

Body site (thickness of stratum corneum)
State of skin 
Occlusion 
Vehicle 
Conc of drug 
Form of drug

Question 28

Which is more potent hydrocortisone acetate or hydrocortisone butyrate/

Answer 28

Hydrocortisone butyrate

Question 29

Which receptors do glucocorticoids signal via?

Answer 29

GRa (nuclear receptor)

Question 30

How do glucocorticoids enter cells?

Answer 30

Diffusion