Dermatitis Flashcards
Features of the acute phases of dermatitis
Papulovesicular Red (erythematous) lesions Oedema (spongiosis) Ooze of scaling & crusting Itchy
Chronic effects of eczema
Thickening (lichenification)
Elevated plaques
Increased scallijg
What type of reaction is contact allergic dermatitis?
Delayed (Type IV) hypersensitivity reaction
What type of reaction is drug related dermatitis?
Type I or IV hypersensitivity reaction
Immunopathology of contact allergic dermatitis
Langerhans cells in the epidermis process antigen
Processed antigen is presented to Th cells in dermis
Sensitised Th celks migrate into lymphatics and then to regional lymph nodes where antigen presentation is amplified
On subsequent antigen challenge specifically sensitised T cells proliferate and migrate to and infiltrate skin
How can specific substances causing allergic contact dermatitis be identified?
Patch testing
What is nappy rash?
Irritant contact dermatitis to urine
What is thenmost important gene in atopic dermatitis?
Filaggrin gene
Clinical features of atopic eczema
Pruritis (sleep disturbance) Ill-defined erythema & scaling Generalised dry skin Flexural distribution Associated with other atopic disease
What does crusting of eczema usually indicate?
Staph aureus infection
Diagnostic criteria for atopic eczema
Itching plus 3 or more
- visible flexural rash
- history of flexural rash (cheeks & extensors in infants)
Personal history of atopy ( or 1st degree relative if
What is the difference between dermatitis & eczema
They are the same thing
Treatment of atopic eczema
EMOLLIENTS Avoid irritants Topical steroids Phototherapy Systemic immunosuppresants
What causes eczema herpecticum?
Eczema infected with herpes simplex virus
Description of lesions of eczema herpecticum
Monomorphic punched-out lesions