Drugs

Question 1

Dilantin/Phenytoin

Answer 1

Potent enzyme inducer, can change efficacy of OCP and other steroids!

Question 2

Cytosine Arabinoside

Answer 2

After several cyces, can develop maybe irreversible cerebellar ataxia
Most common adverse effects of chemo tx = peripheral neuropath w/ docetaxel, paclitax, vincristine, platinum

Question 3

Reversible Posterior Leukoenceph Syndrome

Answer 3

Host of chemotx drugs and cyclosporine, tacrolimus
Htn + confusion + seizure + visual changes - consider this in cancer/transplant
In prego hypertensive, its RPLS, eclamp, or venous throbosis cerebral

Question 4

Haloperidol

Answer 4

Can cause akathesia! If dystonic reaction, give diphenyhydramine (antichol)

Question 5

Parkinsonism causing drugs

Answer 5

Metoclopramide (reglan), Depakote, amphotericin B, haldol

Question 6

Corticosteroids

Answer 6

Can take them for edema after a brain tumor rads therapy,. Weird if steroid taper => emergence of allergice SJS to the AED
Steroids => psychosis hallucinatios, start w/ agitation, sleep distrub, paranoia, maybe need AEDs

Question 7

Valproate

Answer 7

AED most assoc w/ teratogenicity, NTDS, cog develop problems
Also => weight gain and hair loss in user
Parkinsonism possible

Question 8

Carbamazepime adverse rxns?

Answer 8

if take w/ erythromycin => ataxia, nystagmus or worse diplopia. Also happens w/ phenytoin, oxcarbaz

Question 9

Statin adverse effect?

Answer 9

Musculoskeletal symptoms like myopathy w/ normal/elevated CK…can’t get out of chair but normal sense and reflexes

Question 10

Oxcarbazepine effect?

Answer 10

Hyponatremia!! Check lytes within ten days of starting drug

Polypharm w/ thiazide or levetiracetam (Keppra) make it worse!

Question 11

Buproprion s/e?

Answer 11

Lowers seizure threshold, so don’t give to patients w/ migraines!!!

Question 12

TCA benztropine

Answer 12

Tachy, blurred vision, fever, MSE, seeing bugs, takes <12 hours, mydriasis (dilated), dry

Question 13

Neuroleptic Malig Syndrome

Answer 13

Dopamine antagonist after 1-3 days => HTN, tachy, tachyp, hypertherm, sialorrhea, pallor, lead pipe rigidity, bradyreflexic

Question 14

Malignant Hypertherm

Answer 14

Inhaled anesthesia, super high temperatures, mottled looking, rigor mortis like, hyporeflex, agitation

Question 15

Serotonin syndrome

Answer 15

<12 hr, hypertn, tachy, ttachyp, hypertherm, DILATED pupils, sweaty, bowel hyperactive, clonus unmasked, agitation

Question 16

Tacrolimus s/e

Answer 16

Also cyclosporine and other chemo tx => vasc injry + loss of autoreg, hypertension, seizures, confusion and posterior leukoenceph w/ gray matter. Pupils react but can’t see! RPLS!