Drugs

Question 1

Penicillin

Answer 1

inhibition of cell wall synthesis

Question 2

Cephalosporin

Answer 2

inhibition of cell wall synthesis

Question 3

Carbapenems

Answer 3

inhibition of cell wall synthesis

Question 4

Monobactems

Answer 4

inhibition of cell wall synthesis

Question 5

Bacitracin

Answer 5

inhibition of cell wall synthesis - topical use only

Question 6

Vancomycin

Answer 6

inhibition of cell wall synthesis - used against MRSA and antibiotic-associated pseudomembranous colitis cause by Clostridium difficile

Question 7

Cycloserine

Answer 7

inhibition of cell wall synthesis - used against Mycobacterium tuberculosis

Question 8

Isoniazid

Answer 8

inhibition of cell wall synthesis - backbone of therapy for Mycobacterium tuberculosis

Question 9

Chloramphenicol

Answer 9

Inhibition of protein synthesis - used against Hib meningitis, typhoid fever

Question 10

Streptogramins

Answer 10

Inhibition of protein synthesis - used against MRSA, vancomycin-resitant enterococci, drug-resistant Streptococcus pneumoniae

Question 11

Aminoglycosides (-mycin, -micin)

Answer 11

Inhibition of protein synthesis - not efficacious against intracellular bacteria

Question 12

Tetracyclines

Answer 12

Inhibition of protein synthesis - used against intracellular bacteria

Question 13

Oxazolidinones

Answer 13

Inhibition of protein synthesis - used against VRE, MRSA, DRSP

Question 14

Glycycyclines

Answer 14

Inhibition of protein synthesis

Question 15

Macrolides

Answer 15

Inhibition of protein synthesis - used against intracellular bacteria

Question 16

Mupiricin

Answer 16

Inhibition of protein synthesis - used topically to prevent nasal carriage by S. aureus

Question 17

Sulfa (SMX, TMP, co-trimazole, bactrim, septra)

Answer 17

direct inhibition of synthesis of nucleotides - used for uncomplicated UTIs and against pneumocystis carinii in AIDS

Question 18

Fluoroquinolones/quinolones (-floxacin)

Answer 18

direct inhibition of DNA synthesis - used for UTI and lower respiratory tract infection, targets DNA gyrase (topoisomerase II) and topoisomerase IV

Question 19

Rifampin

Answer 19

Inhibition of mRNA synthesis - used to treat carriage of Hib and meningococcus, therapy against Mycobacterium tuberculosis

Question 20

Metronidazole, Tindazole

Answer 20

Damages DNA - used against anaerobic infectious agents

Question 21

Polymyxin

Answer 21

alterations to cell membrane function (forms pores in membrane) - used topically for skin, ear, and eye infections

Question 22

Bacitracin

Answer 22

alterations to cell membrane function (forms pores in membrane) - used topically for skin, ear, and eye infections

Question 23

Daptomycin

Answer 23

alterations to cell membrane function ( loss of membrane potential, rapid depolarization - disrupts multiple aspects of bacterial cell functions

Question 24

Isoniazid

Answer 24

metabolic analog of pyridine/vitamin B6 –> inhibit fatty acid synthesis - backbone therapy against Mycobacterium tuberculosis

Question 25

Sulfa

Answer 25

metabolic analogs of tetrahydrofolic acid and paraaminobenzoic acid –> reduced nucleic acid pool for DNA/RNA synthesis - used for uncomplicated UTIs and against pneumocystis carinii in AIDS