Bacterial Genome Flashcards
Genome
conserved core gene pool + a flexible gene pool
Genome’s conserved core gene pool
generally concerned with basic cellular function/housekeeping genes (GC rich content)
Genome’s flexible gene pool
encode for additional function that are not essential for bacterial growth but are advantageous, can be transferred via HGT
Functional gene pool consists of
Genomic islands: mobile genetic elements >10kb
Genomic islets: mobile genetic elements <10kb
Prophages
Plasmids
Genomic Island
large gene chunk that carries genes for adaptation, signs of mobile elements (phage or plasmid or tRNA), unstable, abnormal CG%, etc
Genomic island advantage
confers survival of organism under adverse conditions
Pathogenicity Island
genomic island associated with pathogenesis
Antibiotic Resistance Island
genomic island containing antibiotic resistant genes