Drugs

Question 1

Lasix targets what?

Answer 1

Na K ATPase pump in the thick ascending loop of Henle

Question 2

MOA of what drug?

• targets Na K ATPase pump in the thick ascending loop of Henle, inhibits pump, Na K not pumped out, stays in the tubule and is wasted in urine.
• check K levels

Answer 2

Lasix

Question 3

-alcohol inhibits ______.

Where?

Answer 3

ADH

Neurons

Question 4

caffeine is a _____antagonist.

Answer 4

adenosine

Question 5

inhibit Na and water reabsorption?

Answer 5

caffeine

Question 6

acetazolamide targets?

-NaHCO3 out

Answer 6

proximal convoluted tubule

Question 7

mannitol targets?

-H20 out

Answer 7

PCT, thin descending loop of henle, collecting duct

Question 8

furosemide (loop diuretics) and adenosine target?

Answer 8

thick ascending loop of Henle

Question 9

thiazides targets?

Answer 9

-distal convoluted tubule

Question 10

mannitol (water), ADH antagonist (water plus ADH), aldosterone antagonist(NaCl plus aldosterone)

Answer 10

collecting duct

Question 11

RC=GFR =____ml/min

Answer 11

125

Question 12

if RC is ______than 125 ml/min the substance is reabsorbed

Answer 12

less than

Question 13

if RC =0 the substance is ____ _____.

Answer 13

completely reabsorbed. ie glucose

Question 14

if RC is ______125 ml/min the substance is secreted (most drug metabolites)

Answer 14

greater than or equal to

Question 15

determine creatinine clearance with what lab?

Answer 15

24 hour urine

Question 16

adenosine targets?

Answer 16

THICK ASCENDING LOOP OF HENLE