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Pharmacology > Drug Toxicity > Flashcards

Drug Toxicity Flashcards

1
Q

How can drug toxicity be measured

A
  • TI
  • MOS (margin of safety)
  • LD50 / TD50
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2
Q

Which adverse effects can occur

A
  • on target
  • off target
  • toxic metabolites
  • harmful immune response
  • idiosyncratic
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3
Q

How can toxic metabolites be produced

A
  • lipid peroxidation
  • reactive oxygen species
  • depletion of glutathione
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4
Q

Which types of hyper-immune responses are there

A

Type 1: immediate hypersens. (IgE)
Type2: Ab dep. cytotoxicity
Type3: Immune complex mediated
Type4: delayed hypersens

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Pharmacology (9 decks)

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