Antihelmintics ll Flashcards
against which types of creatures do these drugs act
- roundworms (nematodes)
- tapeworms (cestodes)
- flukes (trematodes)
Name all 9 groups of drugs with antihelmintic act. (9)
- benzoimidazoles and probenzimidazoles
- macrocyclic lactones
- imidazothiazoles
- isoquinolin and benzazepin derivates
- organophosphates
- piperazines
- tetrahydeopyrimidines
- salicylanilides and substituted phenols
- others
Name the most imp. Salicylanides and substituted phenols (4)
- closantel
- oxyclozanide
- rafoxanide
- Nitroxinil
describe moa for salicylanilides and subst. phenols
uncoupling of oxidative phosphorylation - allowing hydrogen ions to leak through mitoch. membrane
in which species are these used against fasciolosis
cattle and sheep
what are they generally inactive against
nematodes
what is the efficacy against immature flukes
lowered
What is an important pk factor for these drugs
half life
what is the half life of these drugs like
long as there is sign. plasma prot. binding
Do they need wp
yes long wp
Which is excreted in bile duct
oxyclozanide
Why ar3 mature flukes more susceptible
because as they grow they cause haemorrhaging and get in contact with the antihelmintics that way
hat are some side effects of these drugsq
high dosages may cause blindness, hyperthermia, convulsions and death
Name the isoquinolin and benzazepin derivates
praziquantel
epsiprantel
mao of isoquinolin and benzazepin derivates
induction of spastic paralysis - interfering with ca ccq
