Drug Therapy With Aminoglycosides and Fluoroquinolones CH 17 E3

Question 1

Concentration-dependent bactericidal effect

Answer 1

relation of bactericidal ability of a drug to its concentration; the greater the concentration of the drug, the faster and the more extensive the killing of the bacteria. The goal is to maximize concentration of the drug. Once-daily dosing—single daily aminoglycoside dosing, typically using a dose of 7 mg per kg every 24 hours, or longer in patients with renal impairment.

Question 2

Ototoxicity

Answer 2

adverse effects on the structures of the ear, especially the cochlea and auditory nerve

Question 3

Postantibiotic effect

Answer 3

persistent effect of an antimicrobial on bacterial growth after brief exposure of the organisms to a drug