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Pharmacology > drug specifics test 1 > Flashcards

drug specifics test 1 Flashcards

1
Q

H1 agonists (for sleep)

A

can cross BBB

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2
Q

interferon

A

works through all phases of viral process

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3
Q

What not to give in pt with cocaine intoxication

A

beta blockers

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4
Q

carbapenems can cause what at high enough dose

A

seizures

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5
Q

secondary amines

A

norepinephrine effect

sedating/anticholinergic reduced compared to tertiary

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6
Q

AUC/MIC

A 
VANCO
azithromycin
FQs
aminoglycosides
tigencycline
linezolid
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7
Q

MAOIs

A

lots of drug interactions

diet interaction

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8
Q

codeine transformed to

A

morphine

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9
Q

penciclovir and famcclovir

A

varicella and shingles

following activation, inhibit viral DNA synthesis

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10
Q

acyclovir and valacyclovir

A

inhibit viral DNA synthesis

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11
Q

clozapine

A

for recurrent suicidality, violence, comorbid substance abuse
REMS program: neutropenia
only second generation to show superiority to first

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12
Q

flumazenil (romazicon)

A

can cause seizures!

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13
Q

meperidine transformed to

A

normedperidine

build up can lead to seizures

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14
Q

ampho B

A

bind to fungal membrane component (ergosterol) to alter fungal cellular permeability

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15
Q

venlafaxine (effexor)

A

dose related hypertension; discontinuation syndrome

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16
Q

T>MIC

A

B-LACTAMS
vanco
macrolides
clindamycin

17
Q

Fluoxetine (Prozac)

A

CNS activation

18
Q

st. john’s wort interaction

A

CYP inducer

19
Q

Fluvoxamine (luvox)

A

sedating

20
Q

suvorexant (belsomra)

A

orexin antagonist
orexin involved in wakefullness
erection antagonist

21
Q

citalopram (celexa)

A

QT prolongation

22
Q

Escitalopram (lexapro)

A

most selective

23
Q

tertiary amines

A

higher sedation
anticholinergic
serotonin effect

24
Q

Paroxetine (Paxil)

A

sedating

25
Q

duloxetzne (cymbalta)

A

orthostatic hypertension (bad for elderly)

26
Q

azoles

A

inhibit CYP450 enzymes thereby inhibiting fungal ergosterol synthesis

27
Q

ganciclovir and valganciclovir

A

similar MOA to acyclovir (inhibit viral DNA synthesis)

28
Q

sofosbuvir

A

inhibitor of RNA dependent polymerase to terminate viral replication

29
Q

bupropion contraindication

A

seizures

30
Q

Cmax/MIC

A

AMINOGLYCOSIDES

FQs

Pharmacology (14 decks)

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