Drug/Receptor Interactions

Question 1

Four types of pharmacological receptors

Answer 1

Ligand-gated ion channels, G-protein coupled receptors, Kinase-linked receptors, nuclear receptors.

Question 2

Drug-receptor interaction theories.

Answer 2

Occupancy model
Rate model
Induction model
Perturbation model
Cooperativity model

Question 3

Ligand-gated ion channels drug interaction

Answer 3

Milliscond response, membrane bound direct coupling to ion channel

Question 4

G protein receptor drug inetraction

Answer 4

Seconds response, membrane bound but indirect coupling to G protein receptor.

Question 5

Kinase-linked receptor drug interaction

Answer 5

Hours response, direct coupling to enzyme.

Question 6

Nuclear receptor dug interaction

Answer 6

Intracellular, hours response, affects transcription

Question 7

Beta-adrenoreceptors

Answer 7

Activated by isoprenaline, a beta-adrenergic agonist to slow heart rate.

Question 8

Aspirin mode of action

Answer 8

Inhibitor of cyclooxygenase, a non-steroidal anti inflammatory drug, but also used as analgesic and anti-platelet drug.

Question 9

Oubain mode of action

Answer 9

Inhibits Na+ and K+ ATPase increasing intracellular Ca2+. used in heart failure but can be toxic. A cardiac glycoside.