Cholinergic drugs

Question 1

Acetylcholine

Answer 1

Biomolecule involved in postganglion, preganglion and neuromuscular synapse activation.

Question 2

Cholinergic receptors

Answer 2

Nicotine acetylcholine receptors (nAChR)
Muscarine acetylcholine receptors (mAChR)

Question 3

Muscarinic agonists

Answer 3

Primarily affect the parasympathetic system, like vasodilation and heart rate, for example, pilocarpine.

Question 4

Ganglion stimulants

Answer 4

Activate nicotinic receptors affecting both sympathetic and parasympathetic divisions.

Question 5

Ganglionic blockers

Answer 5

Hexamethonium and trimetaphan block transmission between ganglia.

Question 6

Anti-cholinesterases

Answer 6

Inhibit AChE increasing ACh levels in synapses, improving muscle contraction.

Question 7

Neuromuscular blocking drugs

Answer 7

Can be split into: non-polarizing and depolarizing. These drugs reversible/irreversible paralysis of muscles.

Question 8

Acetylcholinesterase inhibitors

Answer 8

By inhibiting this enzyme, these drugs prevent the breakdown of ACh, enhancing cholinergic transmission.