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Step 1 AB > Drug reactions > Flashcards

Drug reactions Flashcards

1
Q

Adrenocortical insufficiency

A

HPA suppression secondary to glucocorticoid withdrawal

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2
Q

Hot flashes

A

Tamoxifene, Clomiphene (antagonist of estrogen receptor at hypothalamus)

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3
Q

Hyperglycemia

A 
Tacrolimus
Protease inhibitors (-navir)
Niacin
HCTZ
Corticosteroids
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4
Q

Hypothyroidism

A

Lithium (LMNOP)
Amiodarone (Check LFTs, TFTs, PFTs)
Sulfonamides

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5
Q

Gynecomastia

A 
Cimetidine
Spironolactone
Estrogen
Digoxin
Chronic alcohol
 Ketoconazole
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6
Q

Acute cholestatic hepatitis, jaundice

A

Erythromycin

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7
Q

Diarrhea

A

Metformin
Erythromycin
Colchicine
Orlistat (inhibits gastric and pancreatic lipase)
Acarbose (inhibits brush border alpha glucosidases)

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8
Q

Focal to massive hepatic necrosis

A

Halothane
Valproic acid
Acetaminophen
Amanita phalloides

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9
Q

Hepatitis

A

Rifampin
Isoniazid
Pyrazinamide
Statins

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10
Q

Pancreatitis

A 
Didanosine (NRTI)
Corticosteroids
Alcohol
Valproic acid
Azathioprine
Diuretics (Furosemide, HCTZ)
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11
Q

Pseudomembranous colitis

A

Clindamycin
Ampicillin
Cephalosporins

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12
Q

Agranulocytosis (Gangs CCCrush Myeloblasts and Promyelocytes)

A 
Ganciclovir
Clozapine
Carbamazepine
Colchicine
Methimazole
Propylthiouracil
Dapsone
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13
Q

Aplastic anemia (Can’t Make New Blood Cells Properly)

A 
Carbamazepine
Methimazole
NSAIDs
Benzene
Chloramphenicol
Propylthiouracil
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14
Q

Direct Coombs positive hemolytic anemia

A

Methyldopa

Penicillin

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15
Q

Gray baby syndrome

A

Chloramphenicol (also causes aplastic anemia)

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16
Q

Hemolysis in G6PD deficiency

A 
Isoniazid
Sulfonamides
Dapsone
Primaquine
Aspirin
Iburprofen
Nitrofurantoin
Fava beans
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17
Q

Megaloblastic anemia

A

Phenytoin
Methotrexate
Sulfa drugs

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18
Q

Thrombocytopenia

A

Heparin

Cimetidine

19
Q

Thrombotic complications

A

OCPs

Hormone replacement therapy

20
Q

Fat redistribution

A

Protease inhibitors

Glucocorticoids

21
Q

Gingival hyperplasia

A

Phenytoin
Calcium channel blockers
Cyclosporine

22
Q

Hyperuricemia

A 
Pyrazinamide
Thiazides
Furosemide
Niacin
Cyclosporine
23
Q

Myopathy

A 
Fibrates
Niacin
Colchicine
Hydroxychloroquine
Interferon alpha
Penicillamine
Statins 
Glucocorticoids
24
Q

Osteoporosis

A

Corticosteroids
Heparin
Avoid PPIs and H2 blockers

25
Q

Photosensitivity

A

Sulfonamides
Amiodarone
Tetracycline
5-FU

26
Q

Rash (Steven’s Johnson) (Steven Johnson has epileptic allergy to sulfa drugs and penicillin)

A

Anti-epileptic
Allopurinol
Sulfa drugs
Penicillin

27
Q

SLE-like syndrome

A 
Sulfa drugs
Hydralazine
Isoniazid
Procainamide
Phenytoin
Etanercept
28
Q

Teeth discoloration

A

Tetracycline

29
Q

Tendonitis, Tendon rupture, cartilage damage

A

Fluoroquinolones (Ciprofloxacin)

30
Q

Cinchonism

A

Quinidine, Quinine

31
Q

Parkinson-like syndrome

A

Antipsychotics, Reserpine, Metoclopramide

32
Q

Seizures

A

Isoniazid
Bupropion
Imipenem
Enflurane

33
Q

Tardive dyskinesia

A

Antipsychotics

Metoclopramide

34
Q

Diabetes insipidus

A

Lithium

Demeclocycline (ADH antagonist)

35
Q

Fanconi syndrome

A

Expired tetracycline

36
Q

Hemorrhagic cystitis

A

Cyclophosphamide, ifosfamide (prevent with mesna)

37
Q

Interstitial nephritis

A

Methicillin
NSAIDs
Furosemide

38
Q

SIADH

A

Carbamazepine
Cyclophosphamide
SSRIs

39
Q

Dry cough

A

ACE inhibitors (from increased bradykinin)

40
Q

Pulmonary fibrosis

A

Bleomycin
Busulfan
Amiodarone
Methotrexate

41
Q

Antimuscarinic

A

Atropine
TCAs
H1 blockers
Anti-psychotics

42
Q

Disulfiram like reaction

A 
Metronidazole
Cephalosporins
Griseofulvins
Procarbazine
1st generation sulfonylureas
43
Q

Nephrotoxicity, Otoxicity

A

Aminoglycosides
Vancomycin
Loop diuretics
Cisplatin (give with Amifostine)

44
Q

What are sulfa drugs?

A 
Probenecid
Furosemide
Acetazolamide
Celecoxib
Thiazides
Sulfonamide Abx
Sulfasalazine
Sulfonylureas

Step 1 AB (29 decks)

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