Drug reactions

Question 1

Adrenocortical insufficiency

Answer 1

HPA suppression secondary to glucocorticoid withdrawal

Question 2

Hot flashes

Answer 2

Tamoxifene, Clomiphene (antagonist of estrogen receptor at hypothalamus)

Question 3

Hyperglycemia

Answer 3

Tacrolimus
Protease inhibitors (-navir)
Niacin
HCTZ
Corticosteroids

Question 4

Hypothyroidism

Answer 4

Lithium (LMNOP)
Amiodarone (Check LFTs, TFTs, PFTs)
Sulfonamides

Question 5

Gynecomastia

Answer 5

Cimetidine
Spironolactone
Estrogen
Digoxin
Chronic alcohol
 Ketoconazole

Question 6

Acute cholestatic hepatitis, jaundice

Answer 6

Erythromycin

Question 7

Diarrhea

Answer 7

Metformin
Erythromycin
Colchicine
Orlistat (inhibits gastric and pancreatic lipase)
Acarbose (inhibits brush border alpha glucosidases)

Question 8

Focal to massive hepatic necrosis

Answer 8

Halothane
Valproic acid
Acetaminophen
Amanita phalloides

Question 9

Hepatitis

Answer 9

Rifampin
Isoniazid
Pyrazinamide
Statins

Question 10

Pancreatitis

Answer 10

Didanosine (NRTI)
Corticosteroids
Alcohol
Valproic acid
Azathioprine
Diuretics (Furosemide, HCTZ)

Question 11

Pseudomembranous colitis

Answer 11

Clindamycin
Ampicillin
Cephalosporins

Question 12

Agranulocytosis (Gangs CCCrush Myeloblasts and Promyelocytes)

Answer 12

Ganciclovir
Clozapine
Carbamazepine
Colchicine
Methimazole
Propylthiouracil
Dapsone

Question 13

Aplastic anemia (Can’t Make New Blood Cells Properly)

Answer 13

Carbamazepine
Methimazole
NSAIDs
Benzene
Chloramphenicol
Propylthiouracil

Question 14

Direct Coombs positive hemolytic anemia

Answer 14

Methyldopa

Penicillin

Question 15

Gray baby syndrome

Answer 15

Chloramphenicol (also causes aplastic anemia)

Question 16

Hemolysis in G6PD deficiency

Answer 16

Isoniazid
Sulfonamides
Dapsone
Primaquine
Aspirin
Iburprofen
Nitrofurantoin
Fava beans

Question 17

Megaloblastic anemia

Answer 17

Phenytoin
Methotrexate
Sulfa drugs

Question 18

Thrombocytopenia

Answer 18

Heparin

Cimetidine

Question 19

Thrombotic complications

Answer 19

OCPs

Hormone replacement therapy

Question 20

Fat redistribution

Answer 20

Protease inhibitors

Glucocorticoids

Question 21

Gingival hyperplasia

Answer 21

Phenytoin
Calcium channel blockers
Cyclosporine

Question 22

Hyperuricemia

Answer 22

Pyrazinamide
Thiazides
Furosemide
Niacin
Cyclosporine

Question 23

Myopathy

Answer 23

Fibrates
Niacin
Colchicine
Hydroxychloroquine
Interferon alpha
Penicillamine
Statins 
Glucocorticoids

Question 24

Osteoporosis

Answer 24

Corticosteroids
Heparin
Avoid PPIs and H2 blockers

Question 25

Photosensitivity

Answer 25

Sulfonamides Amiodarone Tetracycline 5-FU

Question 26

Rash (Steven's Johnson) (Steven Johnson has epileptic allergy to sulfa drugs and penicillin)

Answer 26

Anti-epileptic Allopurinol Sulfa drugs Penicillin

Question 27

SLE-like syndrome

Answer 27

``` Sulfa drugs Hydralazine Isoniazid Procainamide Phenytoin Etanercept ```

Question 28

Teeth discoloration

Answer 28

Tetracycline

Question 29

Tendonitis, Tendon rupture, cartilage damage

Answer 29

Fluoroquinolones (Ciprofloxacin)

Question 30

Cinchonism

Answer 30

Quinidine, Quinine

Question 31

Parkinson-like syndrome

Answer 31

Antipsychotics, Reserpine, Metoclopramide

Question 32

Seizures

Answer 32

Isoniazid Bupropion Imipenem Enflurane

Question 33

Tardive dyskinesia

Answer 33

Antipsychotics | Metoclopramide

Question 34

Diabetes insipidus

Answer 34

Lithium | Demeclocycline (ADH antagonist)

Question 35

Fanconi syndrome

Answer 35

Expired tetracycline

Question 36

Hemorrhagic cystitis

Answer 36

Cyclophosphamide, ifosfamide (prevent with mesna)

Question 37

Interstitial nephritis

Answer 37

Methicillin NSAIDs Furosemide

Question 38

SIADH

Answer 38

Carbamazepine Cyclophosphamide SSRIs

Question 39

Dry cough

Answer 39

ACE inhibitors (from increased bradykinin)

Question 40

Pulmonary fibrosis

Answer 40

Bleomycin Busulfan Amiodarone Methotrexate

Question 41

Antimuscarinic

Answer 41

Atropine TCAs H1 blockers Anti-psychotics

Question 42

Disulfiram like reaction

Answer 42

``` Metronidazole Cephalosporins Griseofulvins Procarbazine 1st generation sulfonylureas ```

Question 43

Nephrotoxicity, Otoxicity

Answer 43

Aminoglycosides Vancomycin Loop diuretics Cisplatin (give with Amifostine)

Question 44

What are sulfa drugs?

Answer 44

``` Probenecid Furosemide Acetazolamide Celecoxib Thiazides Sulfonamide Abx Sulfasalazine Sulfonylureas ```