Bacteria Flashcards
What kind of bacteria is Staph aureus?
Gram + cocci in clusters Catalase + (Strep is Catalase (-)) Coagulase + (converts fibrinogen to fibrin; compared to other Staph) Beta hemolytic Ferments mannitol (turns agar yellow)
What is the main virulence factor of Staph aureus? What is it’s function?
Protein A; it is part of the cell wall and binds FC portion of antibody; inhibits phagocytosis and complement activation
What part of the body is normally colonized with Staph aureus?
Nares (opening of nose)
Inflammatory diseases caused by Staph aureus (5)
- Pneumonia - patchy infiltrate on X-ray; secondary post viral super infection most often
- Joint problems - septic arthritis
- Skin infections - cellulitis, boils, abscesses
- Acute bacterial endocarditis - IV drug user (Right sided heart infection - tricuspid) (rapid onset, acute)
- Osteomyelitis - Most common cause
Toxin mediated diseases caused by Staph aureus
- Scalded skin syndrome - mediated by exfoliative toxin
- Toxic shock syndrome - super antigen; from foreign package being left in too long
- Food poisoning - Rapid onset from preformed toxin (1-8 hours); vomiting; from meats and cream based foods (mayonnaise)
- MRSA - Alters PBP’s to get away from Methicillin; treatment is Vancomycin or Nafcillin
What should you use to treat MRSA?
Vancomycin
Nafcillin
What kind of bacteria is Staph epidermidis? (5)
Gram + cocci Catalase + Coagulase - Urease + Novobiocin sensitive (opposite of Staph saprophyticus)
What kind of bacteria is Staph saprophyticus? (5)
Gram + cocci Catalase + Urease + Coagulase - Novobiocin resistant (opposite of Staph epidermidis
What does Staph epidermidis classically infect?
- Artificial joints and catheters; covers everywhere
2. Endocarditis for artificial heart valves - most common cause of artificial valves
What do you treat Staph epidermidis endocarditis? Why?
Vancomycin; it is resistant to many ABx
Why is Staph epidermidis so good at infecting plastic/foreign surfaces?
Can produce adherent biofilms
What disease does Staph saprophyticus cause?
UTI in sexually active females - SECOND most common cause behind E. coli
What does Staph epidermidis contaminate?
Blood cultures; component of normal skin flora
What kind of bacteria is Strep pyogenes?
Gram positive cocci in chains/pairs (Group A)
Catalase -
Beta hemolytic
Bacitracin sensitive
What kind of bacteria is Strep agalactiae?
Gram positive cocci in chains (Group B)
Catalase -
Beta hemolytic
Bacitracin RESISTANT
Pyogenic diseases that Strep pyogenes causes (2)
- Pharyngitis - strep throat
- Impetigo - honey crusted
- Cellulitis
- Erysipelas - most common cause of
Toxigenic diseases that Strep pyogenes causes (2)
- Scarlet fever - strawberry tongue, pharyngitis, rash that spares face
- Toxic shock like syndrome - super antigen - SpeA, SpeC
- Necrotizing fasciitis - SpeB
Immunologic diseases that Strep pyogenes causes (2)
- Rheumatic fever
2. Post-Strep Glomerulonephritis
Impetigo more commonly precedes __________ than ________.
Impetigo more commonly precedes glomerulonephritis than pharyngitis.
How do you detect Strep pyogenes infection?
ASO titer
Treating S. pyogenes with Penicillin can prevent which complications?
Penicillin can prevent Acute Rheumatic Fever
It CANNOT prevent Acute Glomerulonephritis
Signs of Post-Strep Glomerulonephritis
Type III hypersensitivity
Coca cola colored urine and facial puffiness 2 weeks after Strep infection
What is responsible for Acute Rheumatic Fever after Strep infection?
M protein - it interferes with opsonization and is similar to antigen on cardiac myocytes (Strong humoral response created against it)
What does Streptokinase do? What bacteria has it?
Strep pyogenes; it converts plasminogen to plasmin