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Drug Of Choice Flashcards

1
Q

Mucormycosis

A

Am-b

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2
Q

Kala Azar

A

Am-b

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3
Q

Systemic candida meningitis

A

Am-b

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4
Q

Coccidioidal meningitis

A

Fluconazole

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5
Q

Mucocutaneous candidiasis (albicans only)

A

Fluconazole

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6
Q

Oral candidiasis

A

Topical clotrimazole

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7
Q

Dermatophytes

A

Itraconazole I

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8
Q

Sporotrichosis

A

Itraconazole

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9
Q

Endemic mycoses

A

Itraconazole

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10
Q

Invasive aspergillosis

A

Voriconazole

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11
Q

Prophylaxis of invasive aspergillosis

A

Posaconazole

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12
Q

Gvhd antifungal

A

_Posaconazole

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13
Q

Tinea capitis

A

Griseofulvin

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14
Q

Non albican candida

A

Echinocandins

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15
Q

Onychomycosis

A

Oral terbinafine

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16
Q

Doc partial seizure

A

Carbamazepine

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17
Q

Absent seizures

A

Valproate

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18
Q

GTCS

A

Valproate

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19
Q

Atypical absent seizure

A

Valproate

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20
Q

Doc liver toxicity & hyperammonemia

A

Carnitine

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21
Q

Typical absent seizures

A

Ethosuximide

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22
Q

Trigeminal neuralgia

A

Carbamazepine

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23
Q

Infantile spasm with tuberous sclerosis

A

Vigabatrin

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24
Q

DOC in infantile spasms without tuberous sclerosis

A

ACTH or steroids

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25
Q

Post herpetic neuralgia, DOC:

A

Gabapentin

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26
Q

Safest anti epileptic in pregnancy

A

Levertiracetam

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27
Q

Status epilepticus DOC

A

Lorazepam

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28
Q

DOC Febrile seizure with RoA

A

Rectal diazepam

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29
Q

Drug of choice for seizure in neonates

A

Phenobarbital

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30
Q

DOC Criggler Najar syndrome type 2

A

Phenobarbital

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31
Q

Sleep maintenance, drug of choice

A

DORA

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32
Q

DOC post anaesthetic chills

A

Pethidine/ Meperidine

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33
Q

DOC chills caused by monoclonal antibodies

A

Pethidine/ Meperidine

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34
Q

DOC non-secretory diarrhoea

A

Loperamide

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35
Q

Opioid toxicity drug of choice

A

Naloxone

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36
Q

Prophylaxis of mania drug of choice

A

Lithium

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37
Q

Drug of choice for bipolar disorder

A

Lithium

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38
Q

Drug of choice for acute mania

A

Lithium

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39
Q

Drug of choice for hypnic headache

A

Lithium

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40
Q

Lithium induced DI doc

A

Amiloride

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41
Q

Drug of choice for mania during pregnancy

A

Aripiprazole

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42
Q

Depression DOC

A

SSRI

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43
Q

Cheese reaction DOC

A

Phentolamine IV
alpha blocker

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44
Q

TCA toxicity DOC

A

Sodium bicarbonate

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45
Q

DOC PMS

A

SSRI

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46
Q

DOC neurosis

A

SSRI

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47
Q

DOC depression assoc w insomnia or erectile dysfunction

A

Mirtazapine / Mianserin

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48
Q

DOC morphine poisoning

A

Naloxone

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49
Q

DOC Resistant schizophrenia

A

Clozapine

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50
Q

DOC suicidal tendency in psychosis

A

Clozapine
Due to D4 block

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51
Q

DOC Levodopa induced psychosis

A

Pimavanserin

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52
Q

DOC akathisia

A

B#

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53
Q

DOC to overcome Parkinsonism

A

Anticholinergics- Benzhexol
Other: benztropine , biperiden

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54
Q

DOC Tardive dyskinesia

A

VMAT2 inhibitors like Valbenazine, deutetrabenazine

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55
Q

DOC for NMS (neuroleptic malignant syndrome)

A

Dantrolene

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56
Q

DOC Malignant hyperthermia

A

Dantrolene

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57
Q

DOC Alzheimer’s

A

Donepezil

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58
Q

DOC PD >65 years

A

Levodopa

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59
Q

DOC (?) levodopa induced dyskinesia

A

Amantidine > Leviteracetam

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60
Q

DOC on off phenomenon in PD

A

COMT inhibitors peripheral - Entacapone, Opicapone

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61
Q

DOC hyperprolactinemia in female planning for pregnancy

A

Bromocriptine

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62
Q

DOC hyperprolactinemia

A

Cabergoline

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63
Q

DOC restless leg syndrome

A

Non ergot alkaloids - pramipexole, ropinirole, rotigotine

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64
Q

DOC PD <65 years

A

Non ergot alkaloids

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65
Q

DOC obesity

A

Liraglutide

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66
Q

DOC DM type 2

A

Metformin

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67
Q

DOC prophylaxis of pre diabetes

A

Metformin

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68
Q

DOC acromegaly

A

Octreotide LAR or lanreotide

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69
Q

DOC secretory diarrhoea

A

Somatostatin analogues

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70
Q

DOC glucagonoma, VIPoma, GRFoma

A

Somatostatin analogues

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71
Q

DOC somatostatinomas

A

Somatostatin analogues (yep. I know.)

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72
Q

DOC Insulinoma

A

Diazoxide

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73
Q

DOC acute variceal bleed

A

Terlipressin

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74
Q

DOC prostate cancer

A

Goserelin

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75
Q

DOC replacement of glucocorticoids in Addison’s disease , congenital adrenal hyperplasia

A

Hydrocortisone

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76
Q

DOC post menopausal osteoporosis

A

Oral bisphosphonates

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77
Q

DOC hypercalcemia of malignancy

A

Bisphosphonates

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78
Q

DOC pagets disease

A

Bisphosphonates

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79
Q

Overall DOC for hyperthyroidism

A

Methimazole

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80
Q

DOC hypothyroidism in pregnancy 1st trimester

A

Propylthiouracil

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81
Q

DOC for hyperthyroidism in lactation

A

PTU

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82
Q

DOC for severe thyrotoxicosis

A

PTU
However, the first drug administered is propanolol to prevent arrhythmia

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83
Q

Drug of choice in surgical prophylaxis (anti bacterial)

A

Cefazolin

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84
Q

DOC Gonorrhea

A

Ceftriaxone

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85
Q

DOC meningitis except Listeria

A

Ceftriaxone

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86
Q

DOC pseudomonas

A

Ceftazidime

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87
Q

DOC meliodosis

A

Ceftazidime

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88
Q

DOC febrile neutropenia

A

Ceftazidime

89
Q

DOC E.coli

A

Ceftriaxone

90
Q

DOC Klebsiella

A

Ceftriaxone

91
Q

DOC providencia

A

Ceftriaxone

92
Q

Oral DOC typhoid

93
Q

DOC ESBL

A

Imipenem + cilastatin

94
Q

DOC serratia

95
Q

DOC acinetobacter

96
Q

DOC enterobacter

97
Q

Close angle glaucoma drug of choice

A

Pilocarpine

98
Q

Drug of choice for anticholinergic poisoning

A

Physostigmine

99
Q

Drug of choice for Alzheimer’s disease

100
Q

Drug of choice for Myasthenia gravis

A

Pyridostigmine

101
Q

Drug of choice for treatment of myasthenic crisis

A

Intravenous immunoglobulin

102
Q

Drug of choice for narco analysis

A

Thiopentone

103
Q

Drug of choice for COPD (class)

A

Anti cholinergics
As the only reversible component of broncho constriction in COPD is the parasympathomimetic effect

104
Q

Drug of choice class for bronchi asthma

A

Beta two agonists, because they are the physiological antagonist for histamine, which is responsible for broncho constriction

105
Q

Drug of choice for motion sickness

A

Scopolamine

106
Q

Drug of choice for steroid resistant nephrotic syndrome and ulcerative colitis

A

Cyclosporine

107
Q

Drug of choice for early onset, nausea and vomiting in cancer chemotherapy

A

Ondansetron as it is short acting

108
Q

Drug of choice for late onset, nausea and vomiting in cancer chemotherapy

A

Palonosetron or aprepitant

109
Q

Overall drug of choice for nausea and vomiting and cancer chemotherapy

A

Ondansetron

110
Q

Drug of choice for wegeners granulomatosis

A

Cyclophosphamide

111
Q

Drug of choice for steroid dependent nephrotic syndrome

A

Cyclophosphamide

112
Q

Drug of choice for steroid resistant nephrotic syndrome

A

Cyclosporin

113
Q

Drug of choice for prevention of haemorrhagic cystitis in cyclophosphamide

A

Mesna at dose equal to 60% of the dose of cyclophosphamide administered

114
Q

Regimen of choice for Hodgkin disease

A

ABVD
Adriamycin (doxorubicin)
Bleomycin
Vinblastine
Dacarbazine

115
Q

Drug of choice for brain tumour

A

Temozolomide

116
Q

Drug of choice for head and neck cancer

117
Q

Drug of choice for upper GIT cancer

118
Q

Drug of choice for gastric cancer

119
Q

Drug of choice for lower GIT cancer (colorectal and anal)

A

5fluorouracil

120
Q

Drug of choice for urogenital cancer

121
Q

Drug of choice for osteosarcoma

122
Q

Drug of choice for lung carcinoma

123
Q

Treatment of choice for AML

A

Daunorubicin/ Idarubicin + cytarabine

124
Q

Drug of choice for Kaposi sarcoma

A

Doxorubicin

125
Q

Drug of choice for choriocarcinoma

A

Methotrexate

126
Q

DOC carcinomatous meningistis

A

Methotrexate

127
Q

Drug of choice for rheumatoid arthritis

A

Methotrexate

128
Q

Drug of choice for psoriatic arthritis

A

Methotrexate

129
Q

Drug of choice for histiocytosis

A

Vinblastine

130
Q

DOC pancreatic cancer

A

Gemcitabine

131
Q

Drug of choice for myelodysplasia

A

Azacytidine Decitabine

132
Q

Drug of choice for prevention of tumour lysis syndrome

A

Allopurinol

133
Q

Drug of choice for CLL

A

Fludarabine

134
Q

Treatment of choice for CLL

A

FCR
fludarabine
Cyclophosphamide
Rituximab

135
Q

Drug of choice for hairy cell leukaemia

A

Cladribine

136
Q

Drug of choice for refractory histocytosis

A

Cladribine

137
Q

Drug of choice for treatment of delayed diarrhoea due to irinotecan

A

Loperamide

138
Q

Drug of choice for treatment of sickle cell anaemia

A

Hydroxyurea

139
Q

Drug of choice for polycythaemia vera

A

Hydroxyurea
Newer drug anagrelide

140
Q

Drug of choice for essential thrombocytemia

A

Hydroxyurea

141
Q

Drug of choice for treatment of ER positive breast cancer in premenopausal females

142
Q

Drug of choice for reflexes of ER positive breast carcinoma in premenopausal females

143
Q

Drug of choice for Riedels thyroiditis

144
Q

Drug of choice for treatment of Tamoxifen or Letrozole Resistant ER positive breast cancer in post menopausal , female

A

Fluvestrant

145
Q

Drug of choice for treatment of ER positive breast cancer in post menopausal female

146
Q

Drug of choice for infertility caused by anovulation

A

Aromatase inhibitors like Letrozole

147
Q

DRug of choice for androgenic alopecia

A

Five. Alpha reductive inhibitors. Like finasteride and dutasteride

148
Q

Drug of choice for multiple myeloma

A

Bortezomib

149
Q

Drug of choice for HER2 positive breast cancer

A

Trastuzumab, Pertuzumab

150
Q

DOC RCC

A

Bevacizumab or Sunitinib

151
Q

DOC HCC

152
Q

DOC CML

153
Q

Drug of choice for multi tyrosine kinase inhibitor resistant CML

A

Onacetaxine

154
Q

DOC hypokalemic periodic paralysis

A

Methenamide

155
Q

DOC acute mountain sickness

A

Oral Acetazolamide

156
Q

DOC pulmonary edema

A

Loop diuretics

157
Q

DOC cerebral edema

158
Q

Drug of choice for hypertension with osteoporosis

159
Q

Drug of choice for cirrhotic edema

A

Spironolactone

160
Q

DOC resistant hypertension

A

Spironolactone

161
Q

DOC resistant edema

A

Spironolactone

162
Q

DOC Liddle syndrome

163
Q

DOC lithium induced diabetes inspidus

164
Q

DOC acute congestive glaucoma

165
Q

DOC acute variceal bleeding

A

Terlipressin over octreotide

166
Q

DOC Central DI

A

Desmopressin

167
Q

DOC nocturnal enuresis

A

Desmopressin

168
Q

DOC von willebrand disease

A

Desmopressin

169
Q

DOC haemophilia A

A

Desmopressin

170
Q

DOC Huntington chorea

A

Tetrabenazine & Deutetrabenazine

171
Q

DOC for tardive dyskinesia

A

Deutetrabenazine and Valbenazine

172
Q

DOC for cocaine dependence

A

Bromocriptine

173
Q

DOC vasodilatory shock (sepsis)

A

Norepinephrine

174
Q

DOC cardiogenic shock

A

NorEpinephrine

175
Q

DOC cardiac arrest

A

Epinephrine (1:10,000)

176
Q

DOC anaphylactic shock

A

Epinephrine 1:1000 IM

177
Q

Inotrope of choice in acute CHF

A

Dobutamine

178
Q

DOC priapism

A

Phenylephrine

179
Q

DOC spinal anesthesia induced hypotension

A

Phenylephrine
Exception: if there is associated bradycardia then doc is ephedrine

180
Q

DOC postural hypotension

181
Q

DOC HTN urgency

182
Q

DOC pregnancy induced HTN

A

Oral Labetolol

183
Q

DOC ADHD

A

Methylphenidate

184
Q

DOC ADHD with Tourette syndrome/family history of drug abuse

A

Atomoxetine
Viloxazine

185
Q

DOC narcolepsy

186
Q

DOC OSA, shift worker disease

187
Q

DOC clonidine withdrawal hypertension

A

Phentolamine

188
Q

DOC intraoperative HTN in pheochromocytoma

A

Phentolamine

189
Q

DOC preoperative HTN in pheochromocytoma

A

Phenoxybenzamine

190
Q

TOC in pheochromocytoma

A

Alpha blocker followed by beta blocker

191
Q

DOC BPH+HTN

A

Alpha 1 blockers
Prazosin

192
Q

DOC BPH ( no HTN)

A

Alpha 1A blocker
Tamsulosin
Silodosin

193
Q

DOC scorpion bite

194
Q

DOC migraine ppx

A

Beta blockers

195
Q

DOC essential tremor

A

Beta blockers

196
Q

DOC stable angina

A

Beta blockers

197
Q

DOC hyperobstructive cardiomyopathy

A

Beta blockers

198
Q

DOC aortic dissection

A

Beta blockers

199
Q

Drug of choice for neurosurgery anaesthesia

A

Thiopentone sodium

200
Q

Drug of choice for daycare anaesthesia

201
Q

Drug of choice for cardiac surgeries anaesthesia

202
Q

DOC morning sickness

A

Doxylamine

203
Q

DOC urticaria

A

Second generation antihistamines

204
Q

DOC allergic rhinitis

205
Q

DOC hereditary angioedema treatment

A

C1 esterase inhibitors

206
Q

DOC PPx of hereditary angioedema

207
Q

DOC migraine in pregnancy

A

Paracetamol

208
Q

DOC cervical ripening

A

Dinoprostone

209
Q

DOC open angle glaucoma

A

PGF 2Alpha analogs Latanoprost, Bimatoprost

210
Q

DOC normal tension, glaucoma

A

PGF2 alpha analogues Latanoprost, Bimatoprost

211
Q

DOC niacin induced flushing

212
Q

DOC acute gout

A

Indomethacin

213
Q

DOC paroxysmal hemicrania

A

Indomethacin

214
Q

DOC closure of patent ductus arteriosus in India

215
Q

DOC closure of patent ductus arteriosus international

A

Indomethacin

216
Q

DOC, chronic gout

A

Allopurinol

217
Q

DOC tumour lysis syndrome (high risk)

A

Rasburicase

218
Q

DOC hyperuricemia in lesch nyhan syndrome

A

Allopurinol

219
Q

DOC tumour lysis syndrome (low to moderate risk)

A

Allopurinol

Pharmacology (8 decks)

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