Antifungal Drugs Flashcards
1
Q
Site of action of amphotericin -B ( cw / cm)?
A
Cell membrane - sequesters ergosterol
2
Q
Drug which acts by inhibiting cell wall synthesis (fungi)?
A
Echinocandins, ibrexafungerp
3
Q
Drugs which act by Cell membrane synthesis inhibition in fungi?
A
Terbinafine, azoles
4
Q
Terbinafine blocks which enzyme?
A
SQUALENE epoxidase
5
Q
AZOLES block?
A
14 alpha sterol demethylase
6
Q
First oral azole
A
Ketoconazole
7
Q
Secondary use in cushing’s (antifungal)
A
Ketoconazole
8
Q
Antifungals concentrated in keratin
A
Terbinafine, griseofulvin
