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Pharmacology > Antiprotozoal And Antimalarial Drugs > Flashcards

Antiprotozoal And Antimalarial Drugs Flashcards

1
Q

DOC asymptomatic amoebiasis

A

Paromomycin

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2
Q

DOC Symptomatic amoebiasis

A

Metronidazole

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3
Q

DOC Extraintestinal amoebiasis

A

Metronidazole

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4
Q

Name nitroimidazoles.

A

Metronidazole
Tinidazole
Secnidazole
Satranidazole
Benznidazole
FEXINIDAZOLE (oral)

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5
Q

Conditions in which metronidazole is DOC

A

Extraintestinal amoebiasis
Bacterial vaginosis
Trichomoniasis
Giardiasis
Bacteroides
Tetanus

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6
Q

Disulfiram like reaction is seen in

A

Metronidazole
Other side effects: metallic taste, red discolouration of urine

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7
Q

DOC cutaneous leishmaniasis

A

Sodium stibogluconate

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8
Q

Oral DOC in kala Azar

A

Miltefosine
Actual DOC: Liposomal Am B

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9
Q

DOC post kala Azar dermal leishmaniasis

A

Miltefosine

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10
Q

DOC Chagas’ disease

A

Benznidazole

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11
Q

DOC cryptosporidiasis

A

Nitazoxanide

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12
Q

MOA nitazoxanide

A

Blocking PFOR that is req for oxidative phosphorylation

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13
Q

DOC Cyclosporiasis

A

Cotrimoxazole

Also doc of isosporiasis and sarcosporiasis

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14
Q

Radical cure of malaria can be achieved by using drugs like

A

Primaquine & tafenoquine ( kills hypnozoites)

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15
Q

Fastest schizontoïdal drugs:

A

Artemisinin

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16
Q

Doc severe falciparum malaria

A

Iv Artesunate continuous infusion 48 hours

17
Q

DOC uncomplicated malaria

A

Vivax → chloroquine (3d)+ primaquine x14days/ tafequinone (once)
In case of chloroquine resistance or falciparum, act is used

18
Q

ACT in all states of India

A

Oral Artesunate + sulfadoxine + pyrimethamine

19
Q

Act in northeastern states

A

Oral artemether + lumefantrine

20
Q

Whorl like corneal deposits are s/e of

A

Amiodarone & chloroquine

21
Q

Drug which causes mosquito infertility

A

Proguanil

22
Q

Tinnitus & vertigo are se of

A

Quinine

23
Q

Which drugs acts on all stages of plasmodium?

A

Primaquine (except erythrocytic weak activity)

24
Q

Gametocidal drugs

A

Chloroquine, primaquine, quinine

25
Q

Cinchonism is characterized by:

A

Tinnitus , named, vomiting ( due to CTZ stimulation & gastric irritation), headache, vertigo, diff in hearing & visual defects

26
Q

Giardiasis drugs

A

Metronidazole, nitazoxanide, quiniodochlor, furazolidone

Pharmacology (8 decks)

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