Drug OD/ Poisoning Flashcards

1
Q

Ethanol- Sx

A
  • Ataxia, dysarthria, depressed sensorium, nystagmus

- Coma, resp depression

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2
Q

Ethanol- Dx

A
  • Blood ethanol concentration

- Dx hypovolemia, hypothermia, infection, trauma or GI bleeding

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3
Q

Ethanol- Tx

A
  • Supportive
  • GI decontamination
  • Thiamine and glucose
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4
Q

Salicylates- Sx

A
  • Nausea, vomiting
  • Hyperventilation
  • Tinnitus
  • Listlessness
  • Seizures
  • Resp alkalosis followed by metabolic acidosis
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5
Q

Salicylates- Dx

A
  • Blood salicylate levels

- Acid-base status

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6
Q

Salicylates- Tx

A
  • Charcoal
  • Irrigation
  • Correct dehydration, hypoglycemia, acidosis
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7
Q

PCP- Sx

A
  • Alternation of severe agitation to quiet stupor
  • Bizzare, paranoid and extreme violence
  • Nystagmus
  • Muscle rigidity, dystonia, seziures
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8
Q

PCP- Dx

A
  • Urine PCP

- Gastric aspirate

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9
Q

PCP- Tx

A
  • Supportive care
  • GI decontamination
  • Diazepam
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10
Q

Acetaminophen- Sx

A
  • Anorexia, nausea, RUQ pain
  • Jaundice 24-73 hrs after ingestion
  • Hepatic failure
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11
Q

Acetaminophen- Dx

A
  • Serum concentration to guide tx
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12
Q

Acetaminophen- Tx

A

N-Acetylcystine

- Within 12-16 hrs of ingestion

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13
Q

Sedative hypnotics- Sx

A
  • Nystagmus
  • Atonia, lethargy, somnolence
  • Resp depression
  • Hypotension
  • Hypothermia
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14
Q

Sedative hypnotics-Dx

A
  • Serum levels misleading due to variety

- Flat EEG, extreme sedation

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15
Q

Sedative hypnotics-Tx

A
  • Tx shock and hypotension
  • Restore temp
  • Fluid replacement
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16
Q

Alkali ingestion- Sx

A
  • Lye, ammonia and detergents
  • Liquifactive necrosis
  • Corrosive burns of airways
  • Mouth and throat pain
  • Dysphagia
  • Drooling
  • Substernal pain
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17
Q

Alkali ingestion- Dx

A

Endoscopy

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18
Q

Alkali ingestion- Tx

A
  • Dilute with saline, milk or water

- Do not induce vomiting

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19
Q

Acid ingestion- Sx

A
  • Toilet bowl cleaners, bleach, battery acid
  • Mouth and throat pain
  • Dysphagia
  • Gastric or esophageal burns
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20
Q

Acid ingestion- Dx

A

Endoscopy

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21
Q

Acid ingestion- Tx

A

Dilute, do not neutralize

- Do not induce vomiting

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22
Q

Opiates- Sx

A
  • Sedation
  • Hypotension
  • Bradycardia
  • Hypothermia
  • Resp depression
  • Pinpoint pupils
  • Pulm edema
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23
Q

Opiates-Dx

A

Regain consxiousness with naloxone admin

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24
Q

Opiates- Tx

A
  • Naloxone injection
  • Nalmefene
  • Support
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25
Q

Organophosphates- Eti

A
  • Cholenesterase inhibitors

- Insectisides, nerve gas

26
Q

Organophosphates- Sx

A

Dumbels

  • Diarrhea
  • Urination
  • Miosis
  • Brochorrhea
  • Emesis
  • Excitation with muscle fasciculation
  • Lacrimation
  • Salvation
  • Death from resp depression
27
Q

Organophosphates- Dx

A
  • Low plasma or RBC cholinesterase level
28
Q

Organophosphates- Tx

A
  • Intensive supportive care
  • Atropine or pralidoxime
  • Avoid aspiration
29
Q

Cocaine- Sx

A
  • Euphoria, excitement, restless ness
  • Toxic psychosis, seizure, hypertension
  • Chest pain, MI, aoritc dissection
30
Q

Cocaine- Tx

A
  • Supportive measures
  • Clears body in 1 hr
  • Manage sympathetic hyperactivity
31
Q

Petrolium distillates - Eti

A
  • Oils, lighter fluid, vaseline, turpentine
32
Q

Petrolium distillates -Sx

A
  • Chocking, gagging or gasping
  • Hypoxia
  • Delayed findings, aspiration penumonia
  • CXR infiltraties
33
Q

Petrolium distillates -Tx

A
  • Gastric lavage

- Symptomatic tx

34
Q

Amphetamines- Sx

A
  • Euphoria
  • Mydriasis
  • Restlessness, psychosis and seizures
  • Hypertension
  • Palpitations and arrhythmias
35
Q

Amphetamines- Dx

A
  • Short 1/2 life, drug levels of little value
36
Q

Amphetamines- Tx

A
  • Diazepam or lorazepam

- Supportive care

37
Q

Tricyclics- Sx

A
  • Amtryptaline, imipramine doxepin
  • Rapid onset of life threatening effects
  • Anticholinergic activity
  • Mydriasis, dry mouth, tachycardia, agitation, hallucinations
  • Rapid coma onset
  • Twitching, myoclonus
  • Wide QRS
38
Q

Tricyclics- Dx

A
  • 3 Cs- Cardiac abn, convulsions, coma

- Wide QRS, prolonged QT

39
Q

Tricyclics- Tx

A
  • Do not induce emesis
  • ECG monitoring
  • Activated charcoal
  • Tx seizures, arrhythmias, hypotension
40
Q

Ferrous sulfate- Sx

A
  • Severe N/V abd pain 1-4 hrs- hemorrhagic gastroenteritis, shock, acidosis
  • Improvement 6-12 hrs
  • Shock, acidosis, coagulopathy and hypoglycemia 12-24 hrs
  • Hepatic poisoning
41
Q

Ferrous sulfate-Dx

A
  • Serum concentration
  • Elevated WBCs
  • CXR
42
Q

Ferrous sulfate- Tx

A
  • IV chelation- deferozamine

- Supportive care

43
Q

Sympathomimetic syndrome

A
  • Elevated BP and pulse
  • Severe HTN, reflex bradycardia
  • High temp
  • Dilated pupil
  • Sweaty skin, dry mucous membranes
  • Agitation, anxious, psychotic
44
Q

Sympathomimetic syndrome- Eti

A
  • Amphetamine
  • Cocaine
  • Ephedrine
  • Psuedoephedrine
45
Q

Sympatholytic syndrome-

A
  • Low BP, pulse and temp
  • Small, pinpoint pupils
  • Obtunsation or comatose
46
Q

Sympatholytic syndrome- Eti

A
  • Barbituates
  • Benzos
  • Sedative hypnotics- GHB , clonidine, opioids
47
Q

Cholinergic syndrome

A
  • Bradycardia
  • Miosis
  • Sweating
  • Hyperperistalsis
  • Bronchorrhea, wheezing, salivation
  • Urinary incontinence
  • Agitation and anxiety
  • Muscle fasciculation
48
Q

Cholinergic syndrome- Eti

A
  • Carbamates
  • Nicotine
  • Organophosphates
49
Q

Anticholinergic syndrome

A
  • Tachycardia
  • Mild HTN
  • High temp
  • Dilated pupil
  • Hot, flushed, dry skin
  • Myoclonus
  • Agitated delrium
50
Q

Anticholinergic syndrome- Eti

A
  • Atropine
  • Anticholinergics
  • Antihistamines
  • Tricyclics
51
Q

Serotonin syndrome

A
  • Tachycardia
  • Diarrhea
  • Hyperthermia
  • Tremor, clonus
  • Agitation and delirium
52
Q

Serotonin syndrome- Eti

A
  • SSRI/ SNRIs
  • TCAs
  • MAOIs
  • Fentanyl
  • Tramadol
53
Q

Synthetic amphetamines- Sx

A
  • Anxiety and agitation
  • HTN, tachy, hypertherm.
  • Hyperactive, AMS- hallucinations
54
Q

Synthetic amphetamines- Eti

A

MDMA, molly, ecstacy

- Effects last 3-5 hrs

55
Q

Synthetic amphetamines- Tx

A
  • Cooling
  • Benzo for seizures
  • Supportive care
56
Q

Synthetic cathinones- Eti

A
  • Bath salts
  • 1-5 hrs
  • Taken repeatedly- awake hrs to days
57
Q

Synthetic cathiones- sx

A
  • Tremors, seizures
  • Irritability, hallucinations
  • CV dysfxn, HTN, N/V
58
Q

Synthetic cathiones- Tx

A
  • Benzos for seizures, sedation

- Antipsych for hallucinations

59
Q

Synthetic cannabinoids- Eti

A

Spyce

  • Smoked or tea infusion
  • Last 3-4 hrs
60
Q

Synthetic cannabinoids- Sx

A
  • AMS- confusion, hallucination, seizures, anxiety
  • Tachy
  • Agitation
61
Q

Synthetic cannabinoids- Tx

A
  • Supportive care
  • Benzos
  • Tx HTN