Drug Interactions

Question 1

What is a pharmacologic drug interaction?

Answer 1

physical/chemical interaction between drugs, drug solutions, environment, etc

Question 2

examples of pharmacologic drug interactions?

Answer 2

doxycycline becomes less active with improper storage (detrimental).

lactated ringers chelates enrofloxacin antibiotic and makes it inactive (detrimental).

Question 3

what is a pharmacodynamic drug interaction?

Answer 3

additive, antagonist, synergistic effect of combining two drugs and the effect on patient. A helpful example is synergistic activity of two antibiotics.

Question 4

what is a pharmacokinetic drug interaction?

Answer 4

interactions which impact the absorption, distribution, metabolism, or excretion of the drug.

Question 5

example of pharmacokinetic interaction?

Answer 5

herbal supplements in combination with prescription drugs can be detrimental. (not regulated by FDA, can have toxic side effects, can affect metabolism of other drugs)