Drug interactions

Question 1

What antibiotics interact with theophylline?

Answer 1

Macrolides eg arithromycin, clarithromycin

Question 2

What two rugs interact with macrolide antibitoics?

Answer 2

Stantins

Theophylline

Question 3

What do ACE inhibitors do with respect to sulfonylureas?

Answer 3

Increase hypoglycaemic effect.

Question 4

What pathway does gradefuit juice block? What drug does this effect?

Answer 4

Cytochrome P450. Interferes with statins - causes more muscle aches.

Question 5

What medicine does st johns wort interfere with?

Answer 5

Oral contraceptive pill.

Question 6

What is a type A drug reaction?

Answer 6

Augmented pharmacologic effects

- dose dependent and predictable

Question 7

What is a type B reaction?

Answer 7

Bizarre effects (or idiosyncratic) -
dose independent and unpredictable

Question 8

What is a type C reaction?

Answer 8

Chronic effects

Question 9

What is a type D reaction?

Answer 9

Delayed effects

Question 10

What is a type E reaction?

Answer 10

End of treatment effects.

Question 11

What is a type F reaction?

Answer 11

Failure of treatment

Question 12

What condition can long term treatment with beta blockers cause?

Answer 12

Diabetes

Question 13

What condition an long term treatment with NSAIDS cause?

Answer 13

Hypertension

Question 14

What is important management in type C treatment?

Answer 14

Monitoring

Question 15

What does abrupt stopping of beta blockers cause?

Answer 15

Angina

Question 16

What biochemical symptoms do yu get in an addisonian crisis?

Answer 16

High pottassium
(Low sodium)
Hypotension
Unwell 
Pigmentation

Question 17

What can cause an addisonian crisis?

Answer 17

Removal of steroids