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Peds > drug interactions > Flashcards

drug interactions Flashcards

1
Q

pharmacokinetic

A

drug B changes levels of Drug A

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2
Q

pharmacodynamic

A

levels dont change of drug B

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3
Q

CYP2C9 substrate /INHIBITOr pair

A

Glybiride/sulfonylurea and SMX/TMP

HYPOGLYCEMIA

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4
Q

CYP2D6 substrate/INHIBITOR pair

A

codeine -> morphine/Paroxetine

- NO active morphine, pain worsens

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5
Q

CYP2D6 substrate/INHIBITOR pair MI

A

metoprolol (substrate)
- fluoxetien
BRADYCARDIA

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6
Q

Statins + grapefruit

A

rhabdomyolysis

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7
Q

other interactions with grapefruit 3A4 substrates

A

sildenafil
statis
benzos
ALL CCB

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8
Q

CYP3A4 inhibitors

A
  • macrolides
  • CCBs
    amiodarone
    antiretroviral
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9
Q

cyp3a4 inducers

A
  • anticonvulsants
  • dexamethasone
  • tamoxifen
  • st john’s wort
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10
Q

clarithromycin + digoxin interaction

A

blocks uptake into lumen of nephron, accumulates in serum

- clarithromycin BLOCKS P-gp pump

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11
Q

P-gp substrate/inhibitor/inducer

A
  • digoxin/macrolide, verapamil/rifampin, dex, st johns wort
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12
Q

Inducer of P-gP

A

Rifampin -

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13
Q

acetaminophen+ warfarin =

A

acetaminophen and warfarin acting together to inhibit clotting - increase risk of bleedng

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14
Q

warfarin is a

A

Vitamin K antagonist -

less clotting factors produced

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15
Q

5 drug interactions with Warfarin

FIRST 2 INhibitors of2C9

A
  • Amiodarone
  • Antibiotics - SMC/TMP/METRO
  • Antidepressant SSRIs
  • analgesics NSAIDs, acetaminophen
  • Antiplatelets - aspirin+ warfarin
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16
Q

hyperkalemia suspects

A 
renal disease
ACE inhibitors
ARBs
K+ supplements
SPIRONOLACTONE
AMILORIDE, TRIAMTERENE
17
Q

other hyperkalemia suspects

A 
Diabetes - low renin low aldo state
NSAIDs
Septra
B blockers
salt substitutes
18
Q

trimethoprim and amiloride look similar

A

increase risk for hyperkalemia

19
Q

42 y.o with clonus - serotonin syndrome

A

Tramadol!
(converts to M1 - like morphine)
processed by CYP2D6

Peds (13 decks)

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