adverse drug reactions

Question 1

type A drug reactions features are

Answer 1

• unwanted but EXPECTED

- DOSE dependent

Question 2

example of a type A drug

Answer 2

Digoxin

Question 3

excess narcotic use

excess epinephrine use

Answer 3

constipation

tachycardia

Question 4

type B drug reactions are

Answer 4

Bizarre - Bad unwanted, unexpected

Question 5

example of a type B reaction

Answer 5

• phenytoin

- anticonvulsant hypersensitivity syndrome

Question 6

adverse reaction of ticlopidine

Answer 6

• hepatic, pancytopenia (neutropenia, septic shock)

Question 7

mild effects of abx

Answer 7

maculopapular rash

Question 8

severe effects of Sulfa TMX/SMP

Answer 8

• toxic epidermal necrolysis

Question 9

type C reaction - drugs -

Answer 9

chronic - increase toxc with dose duration frequency
amiodarone
- methotrexate - immunosuppressant
- aminoglycosides

Question 10

type D reaction drugs - delayed

Answer 10

• doxorubicin (early cardiotox)

- delayed cardiotoxicity- CHF 2-3 months later

Question 11

type E reactions - end of us or withdrawal

Answer 11

• narcotics- and beta blockers

Question 12

type F reactions - failure

Answer 12

clopidogrel - activation by cyp2c19

Question 13

what agent inhibits conversion of inactive clopidogrel

Answer 13

PPIs - omeprazole