Drug interactions Flashcards

1
Q

What is the interaction between clarithromycin and simvastatin?

A

Muscle aching as clarithromycin interacts with the cytochrome P450 system

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2
Q

What is the side effect of prescribing amitriptyline with citalopram?

A

Serotonin syndrome

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3
Q

What drugs can lower the seizure threshold of patients taking phenytoin?

A

SSRIs, TCAs, tramadol

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4
Q

What drugs can reduce the antiplatelet effect of clopidogrel?

A

Omeprazole and fluoxetine

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5
Q

What drug should not be prescribed to a patient on beta blockers?

A

Verapamil

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6
Q

How does rifampicin interact with warfarin?

A

Induces cytochrome P450 system which increases metabolism of warfarin, reducing the anticoagulant effects & reducing INR

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