Drug Induced Disorders

Question 1

Cutaneous drug eruption

Answer 1

Itchy red rash

Maculopapular erythematous eruption

No drainage, warmth or induration

Question 2

Cutaneous drug eruption

Pathognomonic

Answer 2

May present in many forms (SJS)

Most commonly reaction to a drug

Question 3

Cutaneous drug eruption treatment

Answer 3

1. Stop the drug
2. Oral antihistamine
3. Cooling lotion (Sarna, eucerin)

Question 4

Fixed drug eruption

Answer 4

Round pink spot

Single, well demarcated erythematous macular lesion

Question 5

Fixed drug eruption

Pathognomonic

Answer 5

Appears in same spot repeatedly whenever you take the same agent

Appears periodically not all the time

Question 6

Fixed drug eruption

Treatment

Answer 6

Stop the drug

Question 7

Steven Johnson Syndrome

Answer 7

Dusky vesicles

Desquamation

Bullae and erosions of mucous membranes

Question 8

Steven-Johnson syndrome

Answer 8

Less than 10% of skin surface affected

Less likely to die compared to TEN

Question 9

Steven Johnson syndrome

Treatment

Answer 9

1. Stop drug
2. Ophthalmology consult
3. Supportive care

Question 10

Toxic epidermal necorlysis

Answer 10

Painful erosion to mucous membrane

Diffusely erythematous

Multiple bullae, desquamation

Question 11

Toxic epidermal necrolysis

Pathognomonic

Answer 11

Nikolskys sign

30% of the body surface involved

More likely to die

Question 12

Nikolsys sign

Answer 12

Gentle pressure easily produces epidermal detachment

Associated with toxic epidermal necrolysis

Question 13

Toxic epidermal necrolysis

Treament

Answer 13

1. Stop drug
2. IV IgG
3. Supportive Care
4. Ophthalmology consult