drug eruptions

Question 1

what is the most commonly reported drug side effecr

Answer 1

skin eruptions

Question 2

what does exanthematous mean

Answer 2

causes a rash

Question 3

type IV hyper sensitivity

Answer 3

cell mediated delayed response reaction

Question 4

type 1 hypersensitivity mechanism

Answer 4

antibody mediated

Question 5

type 2 hypersensitivity mechanism

Answer 5

cytotoxic reaction

Question 6

type 3 hyper sensitivity

Answer 6

immine complex mediated reactions

Question 7

anaphylaxis and/or urticaria is what type of hypersensitivity

Answer 7

type 1

Question 8

blistering reactions is whqat type of hypersensitivity

Answer 8

type 2

Question 9

purpuria/vasculitis/rash is what type of hypersensitivity

Answer 9

type 3

Question 10

erythema/rash is what type of hypersensitivity

Answer 10

type 4

Question 11

what hypersensitivity is T cell mediated

Answer 11

type 4

Question 12

eczema is what type of reaction

Answer 12

non immunological

Question 13

drug indiced alopecia is what type of reaction

Answer 13

non immunological

Question 14

phototoxicity is what type of reaction

Answer 14

non immunological

Question 15

skin erosion due to topical 5-fluorouracil is what type of reaction

Answer 15

non immunological

Question 16

atrophy due to topical corticosteroids is what type of reaction

Answer 16

non immunological

Question 17

psoriasis is what type of reaction

Answer 17

non immunological

Question 18

pigmentation is what type of reaction

Answer 18

non immunological

Question 19

cheilitis, xerosis is what type of reaction

Answer 19

non immunological

Question 20

what can cause cheilitis

Answer 20

retinoid

Question 21

what can cause asteatotic eczema

Answer 21

statins and retinoids

Question 22

what does xerosis mean

Answer 22

dryness

Question 23

what are risk factors for drugs responsuvke for cutaneous reactions

Answer 23

B lactam, NSAIDs, high molecular weight / hapten - forming drugs, rough dose and half life

Question 24

what kind of reaction is not dose dependent

Answer 24

immunological

Question 25

what is the most common type of drug eruption

Answer 25

exanthematous

Question 26

what type of reaction is exanthematous

Answer 26

type IV

Question 27

appearnace of exanthematous

Answer 27

wide spread symmetrically distributed rash with mucous membranes usually spared

Question 28

presentantion of exanthematous

Answer 28

itch, mild fever, and rash

Question 29

onset of exanthematous (time)

Answer 29

4-21 days after first taking the drug

Question 30

drugs associated with exantheatous reactions

Answer 30

penicillins, sulphonamides, erythromycin, streptomycin, allopurinol, anti epileptics, NSAIs and chloramphenicol

Question 31

urticarial is also known as

Answer 31

hives

Question 32

what is the mechanism of urticarial

Answer 32

IgE type 1 hypersensitibity or diret release of inflammatory mediators

Question 33

what may drug induced urticarial reactions be associated with

Answer 33

angioedema / anaphylaxis

Question 34

what drugs cause drug induced bullous pemphigoid

Answer 34

ACEi, penicillin, furosemide

Question 35

what is stevens-johnson syndrome presentation

Answer 35

flu like symptoms then rash then blisters aand sores

Question 36

what can cause immediate prickling with delayed erythema and pigmentation

Answer 36

chlorpromazide, amiodarone

Question 37

what causes exaggerated easy sunburining

Answer 37

quinine, thiazides, demeclocycline

Question 38

what causes telangiectasia on sun exposed sites

Answer 38

CCBs

Question 39

what causes delayed 3 - 5 days erythema and pigmentation

Answer 39

psoralens

Question 40

what causes increased skin fragility

Answer 40

nalidixic acid, tetracycline naproxen, amiodarone