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dermatology > drug eruptions > Flashcards

drug eruptions Flashcards

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Dermatology Board Prep flashcards
1
Q

what is the most commonly reported drug side effecr

A

skin eruptions

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2
Q

what does exanthematous mean

A

causes a rash

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3
Q

type IV hyper sensitivity

A

cell mediated delayed response reaction

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4
Q

type 1 hypersensitivity mechanism

A

antibody mediated

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5
Q

type 2 hypersensitivity mechanism

A

cytotoxic reaction

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6
Q

type 3 hyper sensitivity

A

immine complex mediated reactions

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7
Q

anaphylaxis and/or urticaria is what type of hypersensitivity

A

type 1

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8
Q

blistering reactions is whqat type of hypersensitivity

A

type 2

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9
Q

purpuria/vasculitis/rash is what type of hypersensitivity

A

type 3

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10
Q

erythema/rash is what type of hypersensitivity

A

type 4

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11
Q

what hypersensitivity is T cell mediated

A

type 4

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12
Q

eczema is what type of reaction

A

non immunological

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13
Q

drug indiced alopecia is what type of reaction

A

non immunological

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14
Q

phototoxicity is what type of reaction

A

non immunological

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15
Q

skin erosion due to topical 5-fluorouracil is what type of reaction

A

non immunological

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16
Q

atrophy due to topical corticosteroids is what type of reaction

A

non immunological

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17
Q

psoriasis is what type of reaction

A

non immunological

18
Q

pigmentation is what type of reaction

A

non immunological

19
Q

cheilitis, xerosis is what type of reaction

A

non immunological

20
Q

what can cause cheilitis

A

retinoid

21
Q

what can cause asteatotic eczema

A

statins and retinoids

22
Q

what does xerosis mean

A

dryness

23
Q

what are risk factors for drugs responsuvke for cutaneous reactions

A

B lactam, NSAIDs, high molecular weight / hapten - forming drugs, rough dose and half life

24
Q

what kind of reaction is not dose dependent

A

immunological

25
Q

what is the most common type of drug eruption

A

exanthematous

26
Q

what type of reaction is exanthematous

A

type IV

27
Q

appearnace of exanthematous

A

wide spread symmetrically distributed rash with mucous membranes usually spared

28
Q

presentantion of exanthematous

A

itch, mild fever, and rash

29
Q

onset of exanthematous (time)

A

4-21 days after first taking the drug

30
Q

drugs associated with exantheatous reactions

A

penicillins, sulphonamides, erythromycin, streptomycin, allopurinol, anti epileptics, NSAIs and chloramphenicol

31
Q

urticarial is also known as

A

hives

32
Q

what is the mechanism of urticarial

A

IgE type 1 hypersensitibity or diret release of inflammatory mediators

33
Q

what may drug induced urticarial reactions be associated with

A

angioedema / anaphylaxis

34
Q

what drugs cause drug induced bullous pemphigoid

A

ACEi, penicillin, furosemide

35
Q

what is stevens-johnson syndrome presentation

A

flu like symptoms then rash then blisters aand sores

36
Q

what can cause immediate prickling with delayed erythema and pigmentation

A

chlorpromazide, amiodarone

37
Q

what causes exaggerated easy sunburining

A

quinine, thiazides, demeclocycline

38
Q

what causes telangiectasia on sun exposed sites

A

CCBs

39
Q

what causes delayed 3 - 5 days erythema and pigmentation

A

psoralens

40
Q

what causes increased skin fragility

A

nalidixic acid, tetracycline naproxen, amiodarone

dermatology (12 decks)

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