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MSK SOH > Drug classes > Flashcards

Drug classes Flashcards

1
Q

NSAIDs - examples

A

Ibuprofen

Naproxen

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2
Q

NSAIDs - definition

A

Non steroidal anti inflammatory drugs

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3
Q

NSAIDs - use

A

To control acute pain and reduce inflammation

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4
Q

NSAIDs - side effects

A

Peptic ulceration
Renal impairment
Increased CV risk
Exacerbation of asthma

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5
Q

Steroids - use

A

For short periods in small doses

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6
Q

Steroids - function

A

Suppress inflammation

Suppress the immune system

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7
Q

steroids - routes of administration

A

Oral
IV
IM

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8
Q

Steroids - mechanism of action

A

Steroids bind to steroid receptor.

The receptor with bound steroid then binds DNA to affect the transcription of genes

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9
Q

How many steroid receptors are there?

A

6

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10
Q

Examples of steroid receptors

A 
Glucocorticoid
Mineralocorticoid
Oestrogen
Progestin
Androgen 
Vit D
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11
Q

Steroids - side effects

A 
Weight gain 
Reduction of osteoblast activity (risk of osteoporosis) 
Fracture risk 
Muscle wasting 
Thin skin 
Fluid retention 
Immunosuppression
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12
Q

Steroids - sick day rules

A

Double steroid use
Never stop taking steroids
If vomiting, give IV steroids

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13
Q

DMARDs - definition

A

Disease Modifying Anti Rheumatic Drugs
Slow acting and take several weeks to take effect
Should be started within 3 months of symptoms starting

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14
Q

DMARDs - first line

A

Methotrexate

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15
Q

DMARDs - methotrexate - route of administration

A

Oral

SC

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16
Q

DMARDs - methotrexate - dosage

A

Administered once per week

17
Q

DMARDs - methotrexate - indications

A

Must be using oral contraception

18
Q

DMARDs - methotrexate - pregnancy

A

It is tetatrogenic
Must be stopped 3 months before attempting conception
Must take oral contraception for 3 months after stopping methotrexate to allow adequate wash out

Switch to sulfasalazine instead

19
Q

DMARDs - methotrexate - side effects

A 
Teratogenic 
Hypersensitivity pneumonitis 
Hepato-toxicity 
Mouth ulcer
Rash
20
Q

DMARDs - second line

A

Sulfalazine

21
Q

DMARDs - sulfasalazine - use

A

Often used in combination with methotrexate

Used instead of methotrexate if patient trying to conceive

22
Q

DMARDs - sulfasalazine - side effects

A

Hepatotoxicity
Rash
Decreased sperm count

23
Q

DMARDs - third line

A

Hydroxychloroquine

24
Q

DMARDs - hydroxychloroquine - side effects

A

Irreversible retinopathy

25
Q

Biologics - definition

A

Target the abnormal part of the immune system

Used when DMARDs are not effective

26
Q

Biologics - examples

A

Anti-TNF therapy (entanercerpt, adalimumab)

27
Q

Biologics - anti TNF therapy - side effects

A

Reactivate latent TB
Increased risk of infection
Increased risk of melanotic skin cancer

MSK SOH (24 decks)

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